CD107a Antibody [1D4B]

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ProSci
Product Code: PSI-99-109
Product Group: Primary Antibodies
Supplier: ProSci
CodeSizePrice
PSI-99-109-0.5mg0.5mg£560.00
Quantity:
Prices exclude any Taxes / VAT

Overview

Host Type: Rat
Antibody Isotype: IgG2a
Antibody Clonality: Monoclonal
Antibody Clone: [1D4B]
Regulatory Status: RUO
Target Species: Mouse
Applications:
  • Immunocytochemistry (ICC)
  • Immunohistochemistry- Frozen Section (IHC-F)
  • Immunoprecipitation (IP)
Shipping:
blue ice
Storage:
Store vial at 2-8˚C

Images

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DC2.4 cells were infected with AF405 labeled M. tuberculosis and stained with Rat Anti-Mouse CD107a-UNLB (Cat. No. 99-109) and anti-ubiquitin followed by secondary antibodies. Image from Seto S, Tsujimura K, Horii T, Koide Y. Autophagy adaptor protein p62-SQSTM1 and autophagy-related gene Atg5 mediate autophagosome formation in response to Mycobacterium tuberculosis infection in dendritic cells. PLoS One. 2013;8(12):e86017. Figure 4(c)
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DC2.4 cells were infected with AF405 labeled M. tuberculosis and stained with Rat Anti-Mouse CD107a-UNLB (Cat. No. 99-109) and anti-ubiquitin followed by secondary antibodies. Image from Seto S, Tsujimura K, Horii T, Koide Y. Autophagy adaptor protein p62-SQSTM1 and autophagy-related gene Atg5 mediate autophagosome formation in response to Mycobacterium tuberculosis infection in dendritic cells. PLoS One. 2013;8(12):e86017. Figure 4(c)

Documents

Further Information

Additional Names:
LAMP-1, lysosomal-associated membrane protein 1
Application Note:
CD107a Antibody [1D4B] for use in flow cytometry, immunohistochemistry / immunocytochemistry, electron microscopy, western blotting, immunoprecipitation, ELISA, and purification assays.
Background:
CD107a, also known as lysosomal-associated membrane protein 1 (LAMP-1), is a heavily glycosylated type I transmembrane protein that constitutes one of the two major sialoglycoproteins on lysosomal membranes that can be used to distinguish lysosomes from other organelles. It is a ligand for galaptin, an S-type lectin present in extracellular matrix, through its recognition of acetyllactosamine oligosaccharide chains and is a ligand for E-selectin-mediated cell adhesion. CD107a is principally expressed in epithelial cells and macrophages in a variety of organs in normal and beige mutant mice. It may function in protecting the inner surface of the lysosomal membrane by forming a barrier to lysosomal hydrolases.
Buffer:
Supplied in borate buffered saline, pH 8.2; No preservatives or amine-containing buffer salts added
Concentration:
0.5 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
Plasma membrane fraction of mouse embryo NIH/3T3 cell line
NCBI Gene ID #:
16783
NCBI Official Name:
lysosomal-associated membrane protein 1
NCBI Official Symbol:
Lamp1
NCBI Organism:
Mus musculus
Physical State:
Liquid
Protein Accession #:
P11438
Research Area:
Innate Immunity
SPECIFICITY:
CD107a
Swissprot #:
P11438
User NOte:
Optimal dilutions for each application to be determined by the researcher.