CD107a Antibody [H4A3] (Biotin)

LAMP-1, lysosome-associated membrane protein 1

CD107a Antibody [H4A3] for use in flow cytometry, immunohistochemistry / immunocytochemistry, electron microscopy, western blotting, and immunoprecipitation assays.

CD107a, also known as lysosomal-associated membrane protein 1 (LAMP-1), is a heavily glycosylated type I transmembrane protein that constitutes the major sialoglycoproteins on lysosomal membranes. It is a ligand for galaptin, an S-type lectin present in extracellular matrix, through its recognition of acetyllactosamine oligosaccharide chains, and is a ligand for E-selectin-mediated cell adhesion. CD107a is expressed by activated T cells, macrophages, dendritic cells, activated platelets, tonsillar epithelium, and some tumor cell lines, including U937 and KG1a. It is also a widely expressed intracellular antigen. LAMP-1 may function in protecting the inner surface of the lysosomal membrane by forming a barrier to lysosomal hydrolases. The upregulation of both CD107a and CD107b on the surface of tumor cell lines has been associated with their enhanced metastatic potential where they may increase adhesion to extracellular matrix and endothelium.

Supplied in PBS/NaN3

Lot specific

Biotin

Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

Human adherent peripheral blood cells

3916

lysosomal-associated membrane protein 1

LAMP1

Homo sapiens

Liquid

P11279

Innate Immunity

CD107a

P11279

Optimal dilutions for each application to be determined by the researcher.