CD11b Antibody [M1/70] (PE-Cy5)

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ProSci
Product Code: PSI-98-647
Product Group: Primary Antibodies
Supplier: ProSci
CodeSizePrice
PSI-98-647-0.1mg0.1mg£524.00
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Overview

Host Type: Rat
Antibody Isotype: IgG2b
Antibody Clonality: Monoclonal
Antibody Clone: [M1/70]
Regulatory Status: RUO
Target Species:
  • Baboon
  • Human
  • Mouse
  • Rabbit
Applications:
  • Immunohistochemistry- Frozen Section (IHC-F)
  • Immunoprecipitation (IP)
  • Western Blot (WB)
Shipping:
blue ice
Storage:
Store vial at 2-8˚C

Images

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BALB/c mouse splenocytes were stained with Rat Anti-Mouse CD11b-SPRD (Cat. No. 98-647) and Rat Anti-Mouse Ly-6G/Ly-6C-PE .
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BALB/c mouse splenocytes were stained with Rat Anti-Mouse CD11b-SPRD (Cat. No. 98-647) and Rat Anti-Mouse Ly-6G/Ly-6C-PE .

Documents

Further Information

Additional Names:
Integrin alphaM, Mac-1alpha, Mac-1, Mo1, CR3, C3biR
Application Note:
CD11b Antibody [M1/70] for use in flow cytometry assays.
Background:
CD11b, the integrin alphaM subunit, combines with CD18, the integrin beta2 subunit, to form the integrin Mac-1, also known as complement receptor 3 (CR3), which mediates adhesion to C3bi and ICAM-1/CD54. Mac-1 is expressed at varying levels on granulocytes, macrophages, dendritic cells, NK cells, and B-1 cells in the peritoneal and pleural cavities. Mac-1 expression is rapidly up-regulated on neutrophils after activation and in the same time period that CD62L is shed from the cell surface. In addition to its role in binding C3bi on opsonized targets and mediation of the subsequent ingestion process, Mac-1 is important as an adhesion molecule in the transendothelial migration of monocytes and neutrophils. Cross-reaction of M1/70 to human CD11b has been observed on monocytes, polymorphonuclear leukocytes, and NK cells.
Buffer:
Supplied in PBS/NaN3 and a stabilizing agent
Concentration:
0.1 mg/mL
Conjugate:
PE-Cy5
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
C57BL/10 mouse splenic T cells and concanavalin A-activated C57BL/10 splenocytes
NCBI Gene ID #:
16409
NCBI Official Name:
Integrin alpha M
NCBI Official Symbol:
Itgam
NCBI Organism:
Mus musculus
Physical State:
Liquid
Protein Accession #:
P05555
Research Area:
Immunology,Neuroscience,Signal Transduction
SPECIFICITY:
CD11b
Swissprot #:
P05555
User NOte:
Optimal dilutions for each application to be determined by the researcher.