CD152 Antibody [9H10]
| Code | Size | Price |
|---|
| PSI-98-911-0.5mg | 0.5mg | £524.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Hamster
Antibody Isotype: IgG
Antibody Clonality: Monoclonal
Antibody Clone: [9H10]
Regulatory Status: RUO
Target Species: Mouse
Applications:
- Immunocytochemistry (ICC)
- Immunohistochemistry- Frozen Section (IHC-F)
Shipping:
blue ice
Storage:
Store vial at 2-8˚C
Documents
Further Information
Additional Names:
CTLA-4, cytotoxic T-lymphocyte protein 4
Application Note:
CD152 Antibody [9H10] for use in flow cytometry, ELISA, blocking, and costimulation assays.
Background:
CD152, also known as CTLA-4, is homologous to the costimulatory molecule CD28. Like CD28, the CD152 molecule binds the family of B7 counter-receptors (CD80 and CD86) on antigen-presenting cells. CTLA-4 is not expressed on resting T lymphocytes but is induced 2-3 days following T cell stimulation via the T cell receptor (TCR) complex. Whereas CD28 provides a positive costimulatory signal, CD152 is a negative regulator of T-cell activation, possibly by inhibiting tyrosine kinase signaling through the TCR through its association with tyrosine phosphatases such as SHP-2.
Buffer:
Supplied in borate buffered saline, pH 8.2; No preservatives or amine-containing buffer salts added
Concentration:
0.5 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
Heat-killed Staphylococcus A bacteria coated with mouse CTLA-4/human IgG1 fusion protein
NCBI Gene ID #:
12477
NCBI Official Name:
cytotoxic T-lymphocyte-associated protein 4
NCBI Official Symbol:
Ctla4
NCBI Organism:
Mus musculus
Physical State:
Liquid
Protein Accession #:
P09793
Research Area:
Immunology
SPECIFICITY:
CD152
Swissprot #:
P09793
User NOte:
Optimal dilutions for each application to be determined by the researcher.