CD154 Antibody [MR1]

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ProSci
Product Code: PSI-98-773
Product Group: Primary Antibodies
Supplier: ProSci
CodeSizePrice
PSI-98-773-0.5mg0.5mg£642.00
Quantity:
Prices exclude any Taxes / VAT

Overview

Host Type: Hamster
Antibody Isotype: IgG
Antibody Clonality: Monoclonal
Antibody Clone: [MR1]
Regulatory Status: RUO
Target Species: Mouse
Applications:
  • Immunocytochemistry (ICC)
  • Immunohistochemistry- Frozen Section (IHC-F)
  • Immunohistochemistry- Paraffin Embedded (IHC-P)
  • Immunoprecipitation (IP)
  • Western Blot (WB)
Shipping:
blue ice
Storage:
Store vial at -20˚C

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Further Information

Additional Names:
CD40L, CD40 ligand, gp39
Application Note:
CD154 Antibody [MR1] for use in flow cytometry, immunohistochemistry, immunoprecipitation, ELISA, and blocking assays.
Background:
CD154, formerly known as CD40 ligand and gp39, is a type II integral membrane protein and a member of the tumor necrosis factor (TNF) family of ligands. It is an important accessory molecule in T cell-B cell costimulatory interactions and is expressed predominantly on activated CD4+ T lymphocytes. It is also present on the surface of activated Th0, Th1, and Th2 T cell clones. Its expression is transient and cyclosporin-sensitive. The MR1 monoclonal antibody binds to murine CD154 with high affinity, blocks binding to CD40, and blocks CD154 function. Administration of this antibody to mice blocks the ability to mount primary and secondary immune responses to TD antigens yet does not alter the immune response to TI antigens.
Buffer:
Supplied in PBS
Concentration:
0.5 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
Activated mouse Th1 clone D1.6
NCBI Gene ID #:
21947
NCBI Official Name:
CD40 ligand
NCBI Official Symbol:
Cd40lg
NCBI Organism:
Mus musculus
Physical State:
Liquid
Protein Accession #:
P27548
Research Area:
Immunology
SPECIFICITY:
CD154
Swissprot #:
P27548
User NOte:
Optimal dilutions for each application to be determined by the researcher.