CD22 Antibody [2D6]
| Code | Size | Price |
|---|
| PSI-98-676-0.5mg | 0.5mg | £597.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rat
Antibody Isotype: IgG1
Antibody Clonality: Monoclonal
Antibody Clone: [2D6]
Regulatory Status: RUO
Target Species: Mouse
Applications:
- Immunohistochemistry- Paraffin Embedded (IHC-P)
- Immunoprecipitation (IP)
- Western Blot (WB)
Shipping:
blue ice
Storage:
Store vial at 2-8˚C
Documents
Further Information
Additional Names:
Lyb-8, Leu-14, BL-CAM
Application Note:
CD22 Antibody [2D6] for use in flow cytometry, immunohistochemistry / immunocytochemistry, immunoprecipitation, and activation assays.
Background:
CD22, also known as Lyb-8, is a heterodimeric transmembrane glycoprotein and a member of a structurally related group of immunoglobulin (Ig) superfamily domain-containing proteins called the sialoadhesin family. It is detected in the cytoplasm early in B cell development (late pro-B cell stage), appears on the cell surface concomitant with IgD, and is found on most IgM+IgD+ mature B lymphocytes. Expression is lost with terminal differentiation of B cells and is absent on plasma cells. Activation of B cells via cross-linking of surface Ig increases CD22 expression. CD22 associates with the B cell receptor (BCR) complex and mediates intercellular adhesion. Its intracellular domain is phosphorylated after antigen receptor cross-linking and is involved in negative regulation of B cell activation.
Buffer:
Supplied in borate buffered saline, pH 8.2; No preservatives or amine-containing buffer salts added
Concentration:
0.5 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
Splenic lymphocyte plasma membranes from CBA x C57 F1 mice
NCBI Gene ID #:
12483
NCBI Official Name:
CD22 antigen
NCBI Official Symbol:
Cd22
NCBI Organism:
Mus musculus
Physical State:
Liquid
Protein Accession #:
P35329
Research Area:
Cancer,Stem Cell,Immunology
SPECIFICITY:
CD22
Swissprot #:
P35329
User NOte:
Optimal dilutions for each application to be determined by the researcher.