CD22 Antibody [2D6] (PE)

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ProSci
Product Code: PSI-98-679
Product Group: Primary Antibodies
Supplier: ProSci
CodeSizePrice
PSI-98-679-0.1mg0.1mg£524.00
Quantity:
Prices exclude any Taxes / VAT

Overview

Host Type: Rat
Antibody Isotype: IgG1
Antibody Clonality: Monoclonal
Antibody Clone: [2D6]
Regulatory Status: RUO
Target Species: Mouse
Applications:
  • Immunocytochemistry (ICC)
  • Immunohistochemistry- Paraffin Embedded (IHC-P)
  • Western Blot (WB)
Shipping:
blue ice
Storage:
Store vial at 2-8˚C

Images

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BALB/c mouse splenocytes were stained with Rat Anti-Mouse CD22-PE (Cat. No. 98-679) and Rat Anti-Mouse CD3-FITC .
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BALB/c mouse splenocytes were stained with Rat Anti-Mouse CD22-PE (Cat. No. 98-679) and Rat Anti-Mouse CD3-FITC .

Documents

Further Information

Additional Names:
Lyb-8, Leu-14, BL-CAM
Application Note:
CD22 Antibody [2D6] for use in flow cytometry assays.
Background:
CD22, also known as Lyb-8, is a heterodimeric transmembrane glycoprotein and a member of a structurally related group of immunoglobulin (Ig) superfamily domain-containing proteins called the sialoadhesin family. It is detected in the cytoplasm early in B cell development (late pro-B cell stage), appears on the cell surface concomitant with IgD, and is found on most IgM+IgD+ mature B lymphocytes. Expression is lost with terminal differentiation of B cells and is absent on plasma cells. Activation of B cells via cross-linking of surface Ig increases CD22 expression. CD22 associates with the B cell receptor (BCR) complex and mediates intercellular adhesion. Its intracellular domain is phosphorylated after antigen receptor cross-linking and is involved in negative regulation of B cell activation.
Buffer:
Supplied in PBS/NaN3 and a stabilizing agent
Concentration:
0.1 mg/mL
Conjugate:
PE
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
Splenic lymphocyte plasma membranes from CBA x C57 F1 mice
NCBI Gene ID #:
12483
NCBI Official Name:
CD22 antigen
NCBI Official Symbol:
Cd22
NCBI Organism:
Mus musculus
Physical State:
Liquid
Protein Accession #:
P35329
Research Area:
Cancer,Stem Cell,Immunology
SPECIFICITY:
CD22
Swissprot #:
P35329
User NOte:
Optimal dilutions for each application to be determined by the researcher.