CD40 Antibody [1C10] (Biotin)

TNFRSF5, Bp50

CD40 Antibody [1C10] for use in flow cytometry and immunoprecipitation assays.

CD40 is a type I cell surface protein belonging to the tumor necrosis factor superfamily of cell surface receptors. In mice it is expressed on B lineage cells, follicular dendritic cells, thymic epithelium, and interdigitating cells in the T-cell zone of secondary lymphoid organs. CD40 first becomes detectable on a subset of small pre-B II cells in bone marrow with the levels of CD40 expression increasing thereafter during B cell maturation. Immature B cells (IgM+IgDloB220lo) express intermediate levels of CD40, whereas mature B cells (IgM+IgDhiB220hi) express high levels. CD40 has a central role in B cell growth and differentiation, and signaling through CD40 in combination with IL-4 reportedly induces immunoglobulin isotype switching and secretion of IgE. The agonistic 1C10 antibody closely resembles gp39/CD40 ligand in its ability to stimulate proliferation of small, resting B lymphocytes in the absence of other cofactors.

Supplied in PBS/NaN3

0.5 mg/mL

Biotin

Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

sCD40

21939

CD40 antigen

Cd40

Mus musculus

Liquid

P27512

Cancer,Immunology,Innate Immunity

CD40

P27512

Optimal dilutions for each application to be determined by the researcher.