CD40 Antibody [1C10]
| Code | Size | Price |
|---|
| PSI-98-768-0.5mg | 0.5mg | £613.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rat
Antibody Isotype: IgG2a
Antibody Clonality: Monoclonal
Antibody Clone: [1C10]
Regulatory Status: RUO
Target Species: Mouse
Application: Flow Cytometry
Shipping:
blue ice
Storage:
Store vial at -20˚C
Documents
Further Information
Additional Names:
TNFRSF5, Bp50
Application Note:
CD40 Antibody [1C10] for use in flow cytometry, immunoprecipitation, activation, and blocking assays.
Background:
CD40 is a type I cell surface protein belonging to the tumor necrosis factor superfamily of cell surface receptors. In mice it is expressed on B lineage cells, follicular dendritic cells, thymic epithelium, and interdigitating cells in the T-cell zone of secondary lymphoid organs. CD40 first becomes detectable on a subset of small pre-B II cells in bone marrow with the levels of CD40 expression increasing thereafter during B cell maturation. Immature B cells (IgM+IgDloB220lo) express intermediate levels of CD40, whereas mature B cells (IgM+IgDhiB220hi) express high levels. CD40 has a central role in B cell growth and differentiation, and signaling through CD40 in combination with IL-4 reportedly induces immunoglobulin isotype switching and secretion of IgE. The agonistic 1C10 antibody closely resembles gp39/CD40 ligand in its ability to stimulate proliferation of small, resting B lymphocytes in the absence of other cofactors.
Buffer:
Supplied in PBS
Concentration:
0.5 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
sCD40
NCBI Gene ID #:
21939
NCBI Official Name:
CD40 antigen
NCBI Official Symbol:
Cd40
NCBI Organism:
Mus musculus
Physical State:
Liquid
Protein Accession #:
P27512
Research Area:
Cancer,Immunology,Innate Immunity
SPECIFICITY:
CD40
Swissprot #:
P27512
User NOte:
Optimal dilutions for each application to be determined by the researcher.