CD49f Antibody [4F10]
| Code | Size | Price |
|---|
| PSI-99-547-0.1mg | 0.1mg | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Mouse
Antibody Isotype: IgG2b
Antibody Clonality: Monoclonal
Antibody Clone: [4F10]
Regulatory Status: RUO
Target Species: Human
Application: Immunohistochemistry- Frozen Section (IHC-F)
Shipping:
blue ice
Storage:
Store vial at 2-8˚C
Documents
Further Information
Additional Names:
Integrin alpha6 chain, VLA-6 alpha chain, platelet gpIc
Application Note:
CD49f Antibody [4F10] for use in flow cytometry, immunohistochemistry, and immunoprecipitation assays.
Background:
CD49f is the 125 kDa integrin alpha6 chain which associates noncovalently with the integrin beta1 subunit (CD29) and with the integrin beta4 (CD104) chain to form, respectively, the very late antigen-6 (VLA-6) and alpha6beta4 integrin heterodimers. VLA-6 is expressed on thymocytes, T lymphocytes, monocytes, and platelets. CD49f/CD29 expression is upregulated on activated T lymphocytes and memory T cells. VLA-6 serves as the laminin receptor on platelets, monocytes, and T cells. VLA-6-mediated binding to laminin provides a costimulatory signal to T cells for activation and proliferation.
Buffer:
Supplied in borate buffered saline, pH 8.2; No preservatives or amine-containing buffer salts added
Concentration:
0.1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
SW1222 human colorectal cell line
NCBI Gene ID #:
3655
NCBI Official Name:
Integrin alpha-6
NCBI Official Symbol:
ITGA6
NCBI Organism:
Homo sapiens
Physical State:
Liquid
Protein Accession #:
P23229
Research Area:
Cell Cycle,Signal Transduction
SPECIFICITY:
CD49f
Swissprot #:
P23229
User NOte:
Optimal dilutions for each application to be determined by the researcher.