CD54 Antibody [YN1/1.7.4]

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ProSci
Product Code: PSI-98-812
Product Group: Primary Antibodies
Supplier: ProSci
CodeSizePrice
PSI-98-812-0.5mg0.5mg£469.00
Quantity:
Prices exclude any Taxes / VAT

Overview

Host Type: Rat
Antibody Isotype: IgG2b
Antibody Clonality: Monoclonal
Antibody Clone: [YN1/1.7.4]
Regulatory Status: RUO
Target Species: Mouse
Application: Flow Cytometry
Shipping:
blue ice
Storage:
Store vial at 2-8˚C

Images

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Frozen section of lamina fibrosa from porcine aortic valve leaflet subjected to bicuspid aortic value wall shear stress was stained with Rat Anti-Mouse CD54-UNLB (Cat. No. 98-812) followed by a secondary antibody and DAPI. Image from Sun L, Chandra S, Sucosky P. Ex vivo evidence for the contribution of hemodynamic shear stress abnormalities to the early pathogenesis of calcific bicuspid aortic valve disease. PLoS One. 2012;7(10):e48843. Figure 5
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BALB/c mouse splenocytes were stained with Rat Anti-Mouse CD54-UNLB (Cat. No. 98-812) followed by Mouse Anti-Rat IgG2b-CY5 .
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Frozen section of lamina fibrosa from porcine aortic valve leaflet subjected to bicuspid aortic value wall shear stress was stained with Rat Anti-Mouse CD54-UNLB (Cat. No. 98-812) followed by a secondary antibody and DAPI. Image from Sun L, Chandra S, Sucosky P. Ex vivo evidence for the contribution of hemodynamic shear stress abnormalities to the early pathogenesis of calcific bicuspid aortic valve disease. PLoS One. 2012;7(10):e48843. Figure 5
BALB/c mouse splenocytes were stained with Rat Anti-Mouse CD54-UNLB (Cat. No. 98-812) followed by Mouse Anti-Rat IgG2b-CY5 .

Documents

Further Information

Additional Names:
ICAM-1, Ly-47
Application Note:
CD54 Antibody [YN1/1.7.4] for use in flow cytometry, immunohistochemistry / immunocytochemistry, western blotting, immunoprecipitation, blocking, and purification assays.
Background:
CD54, a member of the immunoglobulin superfamily of cell surface receptors and also known as Intercellular Adhesion Molecule-1 (ICAM-1), is a type I transmembrane glycoprotein that mediates important cell/cell interactions. CD54 is expressed on endothelial cells, dendritic cells, keratinocytes, and lymphocytes. Its expression is upregulated by inflammatory mediators such as IFN gamma, IL-1, TNF-alpha, lipopolysaccharide, and phorbol esters. Endothelial CD54 contributes to the extravasation of leukocytes from blood vessels, particularly in areas of inflammation. CD54 on antigen-presenting cells contributes to antigen-specific T-cell activation, presumably by enhancing interactions between T cell and antigen-presenting cells. These adhesion reactions are mediated via the binding of CD54 to its major ligands, LFA-1 and Mac-1.
Buffer:
Supplied in borate buffered saline, pH 8.2; No preservatives or amine-containing buffer salts added
Concentration:
0.5 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
Mouse NS-1 cells
NCBI Gene ID #:
15894
NCBI Official Name:
intercellular adhesion molecule 1
NCBI Official Symbol:
Icam1
NCBI Organism:
Mus musculus
Physical State:
Liquid
Protein Accession #:
P13597
Research Area:
Immunology,Signal Transduction
SPECIFICITY:
CD54
Swissprot #:
P13597
User NOte:
Optimal dilutions for each application to be determined by the researcher.