CD54 Antibody [YN1/1.7.4] (Biotin)
| Code | Size | Price |
|---|
| PSI-98-814-0.5mg | 0.5mg | £597.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rat
Antibody Isotype: IgG2b
Antibody Clonality: Monoclonal
Antibody Clone: [YN1/1.7.4]
Regulatory Status: RUO
Target Species: Mouse
Application: Flow Cytometry
Shipping:
blue ice
Storage:
Store vial at 2-8˚C
Documents
Further Information
Additional Names:
ICAM-1, Ly-47
Application Note:
CD54 Antibody [YN1/1.7.4] for use in flow cytometry, immunohistochemistry / immunocytochemistry, western blotting, and immunoprecipitation assays.
Background:
CD54, a member of the immunoglobulin superfamily of cell surface receptors and also known as Intercellular Adhesion Molecule-1 (ICAM-1), is a type I transmembrane glycoprotein that mediates important cell/cell interactions. CD54 is expressed on endothelial cells, dendritic cells, keratinocytes, and lymphocytes. Its expression is upregulated by inflammatory mediators such as IFN gamma, IL-1, TNF-alpha, lipopolysaccharide, and phorbol esters. Endothelial CD54 contributes to the extravasation of leukocytes from blood vessels, particularly in areas of inflammation. CD54 on antigen-presenting cells contributes to antigen-specific T-cell activation, presumably by enhancing interactions between T cell and antigen-presenting cells. These adhesion reactions are mediated via the binding of CD54 to its major ligands, LFA-1 and Mac-1.
Buffer:
Supplied in PBS/NaN3
Concentration:
0.5 mg/mL
Conjugate:
Biotin
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
Mouse NS-1 cells
NCBI Gene ID #:
15894
NCBI Official Name:
intercellular adhesion molecule 1
NCBI Official Symbol:
Icam1
NCBI Organism:
Mus musculus
Physical State:
Liquid
Protein Accession #:
P13597
Research Area:
Immunology,Signal Transduction
SPECIFICITY:
CD54
Swissprot #:
P13597
User NOte:
Optimal dilutions for each application to be determined by the researcher.