CD54 Antibody [15.2]
| Code | Size | Price |
|---|
| PSI-99-388-0.1mg | 0.1mg | £373.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Mouse
Antibody Isotype: IgG1
Antibody Clonality: Monoclonal
Antibody Clone: [15.2]
Regulatory Status: RUO
Target Species: Human
Application: Flow Cytometry
Shipping:
blue ice
Storage:
Store vial at 2-8˚C
Documents
Further Information
Additional Names:
ICAM-1, intracellular adhesion molecule-1, Ly-47
Application Note:
CD54 Antibody [15.2] for use in flow cytometry, immunohistochemistry / immunocytochemistry, western blotting, immunoprecipitation, ELISA, and blocking assays.
Background:
CD54, also known as intercellular cell adhesion molecule-1 (ICAM-1), is a 90 kDa type I transmembrane glycoprotein and a member of the immunoglobulin superfamily. It exhibits a wide tissue distribution being expressed on both hematopoietic and non-hematopoietic cells. ICAM-1 expression on leukocytes is low but is rapidly upregulated upon activation. Expression on endothelium and other non-hematopoietic cells is strongly upregulated by inflammatory mediators. The ligands of CD54 are CD11a/LFA-1alpha and CD11b/Mac-1alpha. Endothelial CD54 contributes to the extravasation of leukocytes from blood vessels particularly in areas of inflammation. CD54 on antigen-presenting cells (APC) contributes to antigen-specific T cell activation presumably by enhancing interactions between T cells and APC.
Buffer:
Supplied in borate buffered saline, pH 8.2; No preservatives or amine-containing buffer salts added
Concentration:
0.1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
Rheumatoid synovial cells and human monocytes
NCBI Gene ID #:
3383
NCBI Official Name:
Intercellular adhesion molecule 1
NCBI Official Symbol:
ICAM1
NCBI Organism:
Homo sapiens
Physical State:
Liquid
Protein Accession #:
P05362
Research Area:
Immunology,Signal Transduction
SPECIFICITY:
CD54
Swissprot #:
P05362
User NOte:
Optimal dilutions for each application to be determined by the researcher.