CD62E/CD62P Antibody [1.2B6] (PE-Cy5)
| Code | Size | Price |
|---|
| PSI-99-407-100tests | 100tests | £597.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Mouse
Antibody Isotype: IgG1
Antibody Clonality: Monoclonal
Antibody Clone: [1.2B6]
Regulatory Status: RUO
Target Species: Human
Applications:
- Immunocytochemistry (ICC)
- Immunohistochemistry (IHC)
Shipping:
blue ice
Storage:
Store vial at 2-8˚C
Documents
Further Information
Additional Names:
E-selectin, P-selectin, ELAM-1, LECAM-2, PADGEM, GMP-140, LECAM-3
Application Note:
CD62E/CD62P Antibody [1.2B6] for use in flow cytometry assays.
Background:
CD62E represents the 97 kDa type I transmembrane glycoprotein E-selectin, also known as endothelial-leukocyte adhesion molecule-1 (ELAM-1). It is expressed on cytokine-stimulated endothelium, weakly on unactivated endothelium, and is absent on leukocytes. Like other selectins, CD62E is an adhesion molecule that contributes to the initial attachment and rolling of leukocytes on endothelial surfaces, a prerequisite for leukocyte extravasation into tissues. CD62P is a 140 kDa membrane glycoprotein formerly known as platelet activation-dependent granule membrane protein (PADGEM) or GMP-140. It is expressed on platelets, megakaryocytes, and epithelium. It is thought to mediate the adhesive interactions of neutrophils and monocytes with endothelium in inflammatory responses and of activated platelets to neutrophils and monocytes in hemostasis. The monoclonal antibody 1.2B6 recognizes a common epitope shared by CD62E and CD62P.
Buffer:
Supplied in PBS/NaN3 and a stabilizing agent
Concentration:
Lot specific
Conjugate:
PE-Cy5
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
TNF stimulated human endothelial cells
NCBI Gene ID #:
6401
NCBI Official Name:
E-selectin
NCBI Official Symbol:
SELE
NCBI Organism:
Homo sapiens
Physical State:
Liquid
Protein Accession #:
P16581
Research Area:
Immunology,Signal Transduction
SPECIFICITY:
CD62E/CD62P
Swissprot #:
P16581
User NOte:
Optimal dilutions for each application to be determined by the researcher.