CD62L Antibody [MEL-14]
| Code | Size | Price |
|---|
| PSI-98-824-0.5mg | 0.5mg | £613.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rat
Antibody Isotype: IgG2a
Antibody Clonality: Monoclonal
Antibody Clone: [MEL-14]
Regulatory Status: RUO
Target Species: Mouse
Application: Flow Cytometry
Shipping:
blue ice
Storage:
Store vial at -20˚C
Documents
Further Information
Additional Names:
L-selectin, LECAM-1, LAM-1, Ly-22, Sell, Lnhr, Lyam-1
Application Note:
CD62L Antibody [MEL-14] for use in flow cytometry, immunohistochemistry, immunoprecipitation, blocking, and cytotoxicity assays.
Background:
CD62L, also known as L-selectin, is a type I transmembrane glycoprotein with lectin-like and epidermal growth factor-like domains. It binds to sialylated oligosaccharide determinants on high endothelial venules (HEV) in peripheral lymph nodes. In the mouse, CD62L is expressed on most thymocytes and on peripheral leukocytes, including B and T lymphocytes, neutrophils, monocytes, and eosinophils. This member of the selectin family of cell adhesion molecules appears to be required for lymphocyte homing to peripheral lymph nodes and for leukocyte extravasation at sites of inflammation. Expression of CD62L on lymphocytes and neutrophils is rapidly down-regulated upon cell activation and the level of CD62L expression, along with other markers, distinguishes naive T cells from effector/memory T cells. The monoclonal antibody MEL-14 blocks in vitro binding of lymphocytes to peripheral lymph node HEV and inhibits in vivo lymphocyte extravasation into peripheral lymph nodes and the late stages of leukocyte rolling.
Buffer:
Supplied in PBS
Concentration:
0.5 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
C3H/eb cloned mouse B cell lymphoma 38C-13
NCBI Gene ID #:
20343
NCBI Official Name:
selectin, lymphocyte
NCBI Official Symbol:
Sell
NCBI Organism:
Mus musculus
Physical State:
Liquid
Protein Accession #:
P18337
Research Area:
Immunology
SPECIFICITY:
CD62L
Swissprot #:
P18337
User NOte:
Optimal dilutions for each application to be determined by the researcher.