CD71 Antibody [RI7217] (Biotin)
| Code | Size | Price |
|---|
| PSI-98-837-0.5mg | 0.5mg | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rat
Antibody Isotype: IgG2a
Antibody Clonality: Monoclonal
Antibody Clone: [RI7217]
Regulatory Status: RUO
Target Species: Mouse
Application: Flow Cytometry
Shipping:
blue ice
Storage:
Store vial at 2-8˚C
Documents
Further Information
Additional Names:
T9, transferrin receptor, TfR
Application Note:
CD71 Antibody [RI7217] for use in flow cytometry, immunocytochemistry, western blotting, immunoprecipitation, and separation assays.
Background:
CD71, a type II transmembrane glycoprotein expressed on the cell surface as a homodimer, is the transferrin receptor. It is essential for the growth of normal and neoplastic cells. It is expressed at low levels on resting B and T lymphocytes but is upregulated during responses to antigens and mitogens presumably reflecting the iron dependence of proliferation. Its expression declines with maturation and differentiation. CD71 plays a critical role in cell proliferation by controlling the supply of iron which is essential for many metabolic pathways through the binding and endocytosis of transferrin, the major iron-carrying protein. It may also be involved in signal transduction via its association with the T cell receptor ? chain. The monoclonal antibody RI7217 inhibits cell proliferation in vitro.
Buffer:
Supplied in PBS/NaN3
Concentration:
0.5 mg/mL
Conjugate:
Biotin
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
DMSO induced Friend erythroleukemia 745.6
NCBI Gene ID #:
22042
NCBI Official Name:
transferrin receptor
NCBI Official Symbol:
Tfrc
NCBI Organism:
Mus musculus
Physical State:
Liquid
Protein Accession #:
Q62351
Research Area:
Cancer,Immunology,Obesity,Signal Transduction
SPECIFICITY:
CD71
Swissprot #:
Q62351
User NOte:
Optimal dilutions for each application to be determined by the researcher.