CD80 Antibody [1G10]
| Code | Size | Price |
|---|
| PSI-98-845-0.5mg | 0.5mg | £524.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rat
Antibody Isotype: IgG2a
Antibody Clonality: Monoclonal
Antibody Clone: [1G10]
Regulatory Status: RUO
Target Species: Mouse
Application: Flow Cytometry
Shipping:
blue ice
Storage:
Store vial at 2-8˚C
Documents
Further Information
Additional Names:
B7-1, Ly-53
Application Note:
CD80 Antibody [1G10] for use in flow cytometry, immunoprecipitation, and blocking assays.
Background:
CD80 (B7-1) is a type I transmembrane glycoprotein and a member of the immunoglobulin superfamily of cell surface receptors. It is constitutively expressed by dendritic cells, monocytes, and peritoneal macrophages. Expression of CD80 on B cells is upregulated after activation by various means including stimulation by LPS, IL-4, and surface Ig receptor crosslinking with peak expression occurring between 48 and 72 hours post-activation. The interaction of CD80 with its ligands, CD28 and CD152 (CTLA-4), provides a potent costimulatory signal for T cells activated through the CD3/T cell receptor complex. The monoclonal antibody 1G10 blocks binding of CTLA-4 to CD80 but it does not block stimulation of T cells by natural antigen-presenting cells.
Buffer:
Supplied in borate buffered saline, pH 8.2; No preservatives or amine-containing buffer salts added
Concentration:
0.5 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
Activated 5C2 cells
NCBI Gene ID #:
12519
NCBI Official Name:
CD80 antigen
NCBI Official Symbol:
Cd80
NCBI Organism:
Mus musculus
Physical State:
Liquid
Protein Accession #:
Q00609
Research Area:
Immunology,Signal Transduction
SPECIFICITY:
CD80
Swissprot #:
Q00609
User NOte:
Optimal dilutions for each application to be determined by the researcher.