CLEC4E Antibody

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ProSci
Product Code: PSI-33-011
Product Group: Primary Antibodies
Supplier: ProSci
CodeSizePrice
PSI-33-011-100ug100ug£662.00
Quantity:
Prices exclude any Taxes / VAT

Overview

Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
  • Human
  • Mouse
  • Rat
Application: Western Blot (WB)
Shipping:
blue ice
Storage:
Aliquot and Store at -20C. Avoid freez-thaw cycles.

Images

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Western blot testing of human samples with CLEC4E antibody at 2ug/ml.
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Western blot testing of human samples with CLEC4E antibody at 2ug/ml.

Documents

Further Information

Application Note:
Western blot: 2-5 ug/ml

Provided assay concentrations are suggestions only, CLEC4E antibody titration may be required for optimal results.
Background:
CLEC4 is a member of the C-type lectin family of proteins that plays a role in inflammatory and immune response. CLEC4E, also called Mincle (Macrophage-inducible C-type lectin), is found on the surface of activated macrophages and phagocytes. It is a receptor for both non-self (fungi and mycobacteria), and self (damaged cells) ligands. Dead cells release SAP130 (Sin3A-Associated Protein, 130kDa), a small nuclear ribonucleoprotein component. CLEC4E senses this and interacts with the ITAM-containing adaptor protein FcRgamma, and via Syk and CARD9 signaling, activates the production of inflammatory cytokines such as TNFa, MIP-2 and IL-6.
Buffer:
PBS with 0.1 mg/ml BSA and 0.05% sodium azide
Concentration:
0.5 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
A recombinant protein fragment from the C-terminal portion of human CLEC4E was used as the immunogen for this antibody.
NCBI Gene ID #:
26253
NCBI Official Name:
C-type lectin domain family 4 member E
NCBI Official Symbol:
CLEC4E
NCBI Organism:
Homo sapiens
Physical State:
Liquid
Purification:
Protein A affinity chromatography
Research Area:
Immunology
Swissprot #:
Q9ULY5
User NOte:
Optimal dilutions for each application to be determined by the researcher