CYLD Antibody
| Code | Size | Price |
|---|
| PSI-33-052-100ug | 100ug | £662.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
- Human
- Mouse
Application: Western Blot (WB)
Shipping:
blue ice
Storage:
Aliquot and Store at -20C. Avoid freez-thaw cycles.
Documents
Further Information
Application Note:
Western blot: 2-5 ug/ml
Provided assay concentrations are suggestions only, CYLD antibody titration may be required for optimal results.
Provided assay concentrations are suggestions only, CYLD antibody titration may be required for optimal results.
Background:
CYLD is involved in multiple physiological processes including immune response, osteoclastogenesis and spermatogenesis. It is a tumor suppressor via its negative regulation of NF-kB activation. CYLD is a deubiquitinase, removing ubiquitin chains from tumor-necrosis factor receptor-associated factor 2 (TRAF2) and thereby preventing its activation of IkB, a regulator of NF-kB. NF-kB remains sequestered in the cytoplasm, unable to translocate to the nucleus and initiate cell survival and oncogenetic signaling.
Buffer:
PBS with 0.1 mg/ml BSA and 0.05% sodium azide
Concentration:
0.5 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
A recombinant protein fragment from the N-termiinal region of human CYLD was used as the immunogen for this antibody.
NCBI Gene ID #:
1540
NCBI Official Name:
CYLD lysine 63 deubiquitinase
NCBI Official Symbol:
CYLD
NCBI Organism:
Homo sapiens
Physical State:
Liquid
Purification:
Protein A affinity chromatography
Research Area:
Cancer, Cell Cycle
Swissprot #:
Q9NQC7
User NOte:
Optimal dilutions for each application to be determined by the researcher