DC-SIGN Antibody
| Code | Size | Price |
|---|
| PSI-33-022-100ug | 100ug | £662.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
- Human
- Mouse
Application: Western Blot (WB)
Shipping:
blue ice
Storage:
Aliquot and Store at -20C. Avoid freez-thaw cycles.
Documents
Further Information
Additional Names:
DC-SIGN Antibody: CDSIGN, CLEC4L, DC-SIGN, DC-SIGN1, CD209 antigen, C-type lectin domain family 4 member L
Application Note:
Western blot: 2-5 ug/ml
Provided assay concentrations are suggestions only, DC-SIGN antibody titration may be required for optimal results.
Provided assay concentrations are suggestions only, DC-SIGN antibody titration may be required for optimal results.
Background:
DC-SIGN (Dendritic Cell-Specific Intercellular adhesion molecule-3-Grabbing Non-integrin) also known as CD209, is part of the Lectin family of proteins. DC-SIGN is part of the innate immune response via its modulation of Toll-like Receptors. It is present on the surface of macrophages and dendritic cells and binds mannose carbohydrates, a class of PAMPS found on bacteria, fungi and viruses. PAMP stimulated DC-SIGN activates the Raf kinases Raf-1 and B-Raf. Raf-1 phosphorylates Ser276 of NF-kB p65 which serves as a binding site for histone acetyltransferases CREB-binding protein (CBP) and p300. Acetylation of NF-kB p65 leads to enhanced and prolonged anti-inflammatory cytokine IL-10 production.
Buffer:
PBS with 0.1 mg/ml BSA and 0.05% sodium azide
Concentration:
0.5 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
A recombinant protein fragment from human DC-SIGN was used as the immunogen for this antibody.
NCBI Gene ID #:
30835
NCBI Official Name:
CD209 molecule
NCBI Official Symbol:
CD209
NCBI Organism:
Homo sapiens
Physical State:
Liquid
Purification:
Protein A purified antibody
Research Area:
Infectious Disease
Swissprot #:
Q9NNX6
User NOte:
Optimal dilutions for each application to be determined by the researcher