EMAP II Antibody
| Code | Size | Price |
|---|
| PSI-33-049-100ug | 100ug | £662.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
- Human
- Mouse
- Rat
Application: Western Blot (WB)
Shipping:
blue ice
Storage:
Aliquot and Store at -20C. Avoid freez-thaw cycles.
Documents
Further Information
Additional Names:
AIMP1 Antibody: p43, HLD3, EMAP2, SCYE1, EMAPII, Aminoacyl tRNA synthase complex-interacting multifunctional protein 1, Multisynthase complex auxiliary component p43, EMAP-2
Application Note:
Western blot: 2-5 ug/ml
Provided assay concentrations are suggestions only, antibody titration may be required for optimal results.
Provided assay concentrations are suggestions only, antibody titration may be required for optimal results.
Background:
EMAP II (Endothelial monocyte-activating polypeptide 2) is a pro-inflammatory cytokine and participant in apoptotic cell death. It is synthesized as a precursor (pro-EMAP II), lacking a secretion signal peptide. In apoptotic cells, the ~34 kDa pro-form of EMAP II is cleaved by Caspase-7 (and Caspase-3 to a lesser extent) at aspartate 144 to its mature, ~20 kDa form. The mature form of EMAP II has been found to have many different functions. In vivo, it recruits leukocytes to the site of apoptotic cell death. In vitro it has been shown to activate endothelial cells (and the release of von Willebrand factor, E-selectin and P-selectin), neutrophils, and induces macrophage expression of TNFa and TF (tissue factor). EMAP II is also a possible biomarker for brain injury, having been found to be differentially expressed in two types: traumatic injury shows an increase and ischemic injury shows a decrease in EMAP II expression (Dave, et al, 2014).
Buffer:
PBS with 0.1 mg/ml BSA and 0.05% sodium azide
Concentration:
0.5 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
A recombinant protein fragment from the C-terminal region of human EMAP II was used as the immunogen for this antibody.
NCBI Gene ID #:
9255
NCBI Official Name:
aminoacyl tRNA synthetase complex interacting multifunctional protein 1
NCBI Official Symbol:
AIMP1
NCBI Organism:
Homo sapiens
Physical State:
Liquid
Purification:
Protein A purified antibody
Research Area:
Immunology
Swissprot #:
Q12904
User NOte:
Optimal dilutions for each application to be determined by the researcher