FADD Antibody [1A11]

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ProSci
Product Code: PSI-99-750
Product Group: Primary Antibodies
Supplier: ProSci
CodeSizePrice
PSI-99-750-0.1mg0.1mg£560.00
Quantity:
Prices exclude any Taxes / VAT

Overview

Host Type: Mouse
Antibody Isotype: IgG1
Antibody Clonality: Monoclonal
Antibody Clone: [1A11]
Regulatory Status: RUO
Target Species: Human
Application: Flow Cytometry
Shipping:
blue ice
Storage:
Store vial at 2-8˚C

Images

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Total cell lysates from Jurkat cells were resolved by electrophoresis, transferred to PVDF membrane, and probed with Mouse Anti-Human FADD-UNLB (Cat. No. 99-750). Proteins were visualized using Goat Anti-Mouse IgG, Human ads-HRP secondary antibody and chemiluminescent detection.
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Total cell lysates from Jurkat cells were resolved by electrophoresis, transferred to PVDF membrane, and probed with Mouse Anti-Human FADD-UNLB (Cat. No. 99-750). Proteins were visualized using Goat Anti-Mouse IgG, Human ads-HRP secondary antibody and chemiluminescent detection.

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Further Information

Additional Names:
FAS-associated death domain protein, GIG3, MGC8528, MORT1
Application Note:
FADD Antibody [1A11] for use in ELISA, western blotting, and immunoprecipitation assays.
Background:
Fas-associated death domain (FADD, also known as MORT1) is an important apoptosis adapter molecule involved in the Fas-mediated cell death pathway. FADD associates with the intracellular domain of FAS (CD95/APO-1) through their respective C-terminal death domains (DD). The N-terminal region of FADD contains a death effectors domain (DED) which recruits and binds cytosolic proteins such as FLICE/caspase-8. The subsequent activation of FLICE by proteolytic cleavage leads to the activation of the caspase-mediated (ICE-related proteases) apoptotic cascade. Overexpression of FADD induces apoptosis which is inhibited by CrmA, a specific inhibitor of the interleukin-1beta-converting enzyme. FADD has also been shown under certain circumstances to promote cell survival and proliferation.
Buffer:
Supplied in borate buffered saline, pH 8.2; No preservatives or amine-containing buffer salts added
Concentration:
0.5 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
Recombinant FADD
NCBI Gene ID #:
8772
NCBI Official Name:
FAS-associated death domain protein
NCBI Official Symbol:
FADD
NCBI Organism:
Homo sapiens
Physical State:
Liquid
Protein Accession #:
Q13158
Research Area:
Cancer,Cell Cycle
SPECIFICITY:
FADD
Swissprot #:
Q13158
User NOte:
Optimal dilutions for each application to be determined by the researcher.