GFAP Antibody [SB61b] (HRP)
| Code | Size | Price |
|---|
| PSI-99-780-1mL | 1mL | £560.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Mouse
Antibody Isotype: IgG2b
Antibody Clonality: Monoclonal
Antibody Clone: [SB61b]
Regulatory Status: RUO
Target Species:
- Human
- Mouse
Applications:
- Immunocytochemistry (ICC)
- Western Blot (WB)
Shipping:
blue ice
Storage:
Store vial at 2-8˚C
Documents
Further Information
Additional Names:
Glial fibrillary acidic protein, intermediate filament protein
Application Note:
GFAP Antibody [SB61b] for use in ELISA, immunohistochemistry / immunocytochemistry, and western blotting assays.
Background:
Glial fibrillary acid protein (GFAP) is a member of the type III intermediate filament family of proteins. GFAP is heavily expressed in astrocytes and certain other astroglia in the central nervous system, in satellite cells in peripheral ganglia, and in non-myelinating Schwann cells in peripheral nerves. It is closely related to its non-epithelial family members, vimentin, desmin, and peripherin, which are all involved in the structure and functions of the cell?s cytoskeleton. GFAP is thought to help to maintain astrocyte mechanical strength, as well as the shape of cell; however, its precise function remains poorly understood. In adults, GFAP levels increase in response to the proliferation of astrocytes associated with Alzheimer?s disease, epilepsy, and multiple sclerosis. Antibodies specific for GFAP are useful as markers of astrocytic cells and neural stem cells as well as for distinguishing neoplasms of astrocytic origin from other neoplasms in the central nervous system.
Buffer:
Supplied in a stock solution of 50% glycerol/50% PBS, pH 7.4; No preservative added
Concentration:
Lot specific
Conjugate:
HRP
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
Recombinant human GFAP
NCBI Gene ID #:
2670
NCBI Official Name:
Glial fibrillary acidic protein
NCBI Official Symbol:
GFAP
NCBI Organism:
Homo sapiens
Physical State:
Liquid
Protein Accession #:
P14136
Research Area:
Neuroscience,Signal Transduction
SPECIFICITY:
GFAP
Swissprot #:
P14136
User NOte:
Optimal dilutions for each application to be determined by the researcher.