Glycoprotein 2 Antibody [GP2/1712]
| Code | Size | Price |
|---|
| PSI-33-696-100ug | 100ug | £765.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Mouse
Antibody Isotype: IgG2b, lambda
Antibody Clonality: Monoclonal
Antibody Clone: GP2/1712
Regulatory Status: RUO
Target Species: Human
Applications:
- Immunofluorescence (IF)
- Immunohistochemistry- Paraffin Embedded (IHC-P)
Shipping:
blue ice
Storage:
Aliquot and Store at -20C. Avoid freez-thaw cycles.
Documents
Further Information
Additional Names:
Pancreatic secretory granule membrane major glycoprotein GP2, Pancreatic zymogen granule membrane protein GP-2, ZAP75, GP2
Application Note:
Flow Cytometry: 0.5-1ug/10e6 cells in 0.1ml
Immunofluorescence: 0.5-1 ug/ml
IHC (FFPE): 1-2 ug/ml for 30 min at RT
Optimal dilution of the GP2 antibody should be determined by the researcher.
Immunofluorescence: 0.5-1 ug/ml
IHC (FFPE): 1-2 ug/ml for 30 min at RT
Optimal dilution of the GP2 antibody should be determined by the researcher.
Background:
GP2 (Glycoprotein 2), also known as ZAP75, is a 537 amino acid secreted protein. It is an integral membrane protein that is secreted from intracellular zymogen granules and associates with the plasma membrane via glycosylphosphatidylinositol (GPI) linkage. GP2 is cleaved and then released into the pancreatic duct along with exocrine secretions. GP2 binds pathogens such as enterobacteria, thereby playing an important role in the innate immune response. The C-terminus of this protein is related to the C-terminus of the protein encoded by the neighboring gene, uromodulin (UMOD). GP2 is also expressed on the apical plasma membrane of specialized microfold (M) cells among enterocytes and serves as a transcytotic receptor for mucosal antigens. M cells are considered a promising target for oral vaccination against various infectious diseases.
Buffer:
PBS with 0.1 mg/ml BSA and 0.05% sodium azide
Concentration:
0.2 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
A partial human recombinant protein corresponding to amino acids 35-179 was used as the immunogen for the GP2 antibody.
NCBI Gene ID #:
2813
NCBI Official Name:
Pancreatic secretory granule membrane major glycoprotein GP2
NCBI Official Symbol:
GP2
NCBI Organism:
Homo sapiens
Physical State:
Liquid
Purification:
Protein G affinity chromatography
Research Area:
Other
SPECIFICITY:
Does not react with Mouse
Swissprot #:
P55259
User NOte:
Optimal dilutions for each application to be determined by the researcher