IL-31 Antibody [SB118b]
| Code | Size | Price |
|---|
| PSI-99-793-0.1mg | 0.1mg | £505.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Mouse
Antibody Isotype: IgG2b
Antibody Clonality: Monoclonal
Antibody Clone: [SB118b]
Regulatory Status: RUO
Target Species: Human
Shipping:
blue ice
Storage:
Store vial at 2-8˚C
Documents
Further Information
Additional Names:
Interleukin-31
Application Note:
IL-31 Antibody [SB118b] for use in ELISA assays.
Background:
Interleukin-31 (IL-31) is a 24 kDa alpha-helical protein and a member of the IL-6 family of cytokines that is preferentially expressed by CD4+ T cells. This cytokine elicits its response by binding to a heterodimeric complex consisting of a gp130-like receptor chain and the oncostatin M receptor subunit. On target cells which include a broad range of immune and non-immune cells, IL-31 binding can induce activation of the Jak/STAT, AKT, and MAPK signaling pathways. Due to the ubiquitous expression of its receptor complex, IL-31 has numerous physiological roles that include regulating hematopoiesis and immune response. Over-expression has been linked to chronic inflammatory states such as dermatitis, pruritus, airway hypersensitivity, and inflammatory bowel disease.
Buffer:
Supplied in borate buffered saline, pH 8.2; No preservatives or amine-containing buffer salts added
Concentration:
1.0 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
E. coli-expressed human IL-31
NCBI Gene ID #:
386653
NCBI Official Name:
interleukin 31
NCBI Official Symbol:
IL31
NCBI Organism:
Homo sapiens
Physical State:
Liquid
Protein Accession #:
Q6EBC2
Research Area:
Immunology,Chemokines & Cytokines
SPECIFICITY:
IL-31
Swissprot #:
Q6EBC2
User NOte:
Optimal dilutions for each application to be determined by the researcher.