CD18 Antibody [68-5A5]

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ProSci
Product Code: PSI-33-421
Product Group: Primary Antibodies
Supplier: ProSci
CodeSizePrice
PSI-33-421-100ug100ug£765.00
Quantity:
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Overview

Host Type: Mouse
Antibody Isotype: IgG2a, kappa
Antibody Clonality: Monoclonal
Antibody Clone: 68-5A5
Regulatory Status: RUO
Target Species: Human
Applications:
  • Functional Study
  • Immunofluorescence (IF)
  • Western Blot (WB)
Shipping:
blue ice
Storage:
Aliquot and Store at -20C. Avoid freez-thaw cycles.

Images

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SDS-PAGE Analysis of Purified, BSA-Free CD18 Antibody (clone 68-5A5). Confirmation of Integrity and Purity of the Antibody.
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SDS-PAGE Analysis of Purified, BSA-Free CD18 Antibody (clone 68-5A5). Confirmation of Integrity and Purity of the Antibody.

Documents

Further Information

Additional Names:
Integrin beta-2, Cell surface adhesion glycoproteins LFA-1/CR3/p150,95 subunit beta, Complement receptor C3 subunit beta, CD18, ITGB2, CD18, MFI7
Application Note:
Functional Activity (Order SAF formulation)

Flow Cytometry: 0.5-1 ug/million cells in 0.1ml

Immunofluorescence: 0.5-1 ug/ml

Optimal dilution of the CD18 antibody should be determined by the researcher.
Background:
It recognizes a transmembrane glycoprotein of 95kDa, identified as CD18 or integrin -2 (Workshop III). It complexes non-covalently with either L, M, or X integrin (CD11a, b, or c) to form the heterodimers, LFA-1, Mac-1, and p150,95, respectively. LFA-1 is the receptor for three members of the Ig supergene family of proteins, ICAM-1 (CD54), ICAM-2 (CD102), and Mac-1 and p150,95 bind to ICAM-1, fibrinogen, and iC3b. ICAM-3 (CD50). CD18/CD11 heterodimeric molecules are involved with cell/cell and cell/extracellular adhesion in immune and inflammatory responses. This mAb blocks these cellular interactions.
Buffer:
PBS with 0.1 mg/ml BSA and 0.05% sodium azide
Concentration:
0.2 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
Stimulated human leukocytes were used as the immunogen for the CD18 antibody.
NCBI Gene ID #:
3689
NCBI Official Name:
integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
NCBI Official Symbol:
ITGB2
NCBI Organism:
Homo sapiens
Physical State:
Liquid
Purification:
Protein G affinity chromatography
Research Area:
Immunology,Signal Transduction
Swissprot #:
P05107
User NOte:
Optimal dilutions for each application to be determined by the researcher