SIN1 Antibody
Code | Size | Price |
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PSI-33-014-100ug | 100ug | £662.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
- Human
- Mouse
- Rat
Application: Western Blot (WB)
Shipping:
blue ice
Storage:
Aliquot and Store at -20C. Avoid freez-thaw cycles.
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Further Information
Additional Names:
MAPKAP1 Antibody: MIP1, SIN1, JC310, SIN1b, SIN1g, MIP1, Target of rapamycin complex 2 subunit MAPKAP1, Mitogen-activated protein kinase 2-associated protein 1, TORC2 subunit MAPKAP1
Application Note:
Western blot: 1-3 ug/ml
Provided assay concentrations are suggestions only, SIN1 antibody titration may be required for optimal results.
Provided assay concentrations are suggestions only, SIN1 antibody titration may be required for optimal results.
Background:
mTOR, or Mammalian target of rapamycin, a large protein kinase, is a regulator of cell growth and survival via its mTORC1 (mTOR + GBL + Raptor) and mTORC2 (mTOR + GBL + SIN1 + Rictor) complexes. SIN1 is an essential component of mTORC2, which activates Akt by phosphorylating Ser473. Phosphorylation of SIN1 at Thr86/398 causes its dissociation from the mTORC2 complex, inhibiting mTORC2s kinase activity.
Buffer:
PBS with 0.1 mg/ml BSA and 0.05% sodium azide
Concentration:
0.5 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
A recombinant protein fragment from the C-terminal region of human SIN1 was used as the immunogen for this antibody.
NCBI Gene ID #:
79109
NCBI Official Name:
mitogen-activated protein kinase associated protein 1
NCBI Official Symbol:
MAPKAP1
NCBI Organism:
Homo sapiens
Physical State:
Liquid
Purification:
Protein A purified antibody
Research Area:
Signal Transduction
Swissprot #:
Q9BPZ7
User NOte:
Optimal dilutions for each application to be determined by the researcher