CD38 Antibody [NIMR-5]
| Code | Size | Price |
|---|
| PSI-98-754-0.5mg | 0.5mg | £673.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rat
Antibody Isotype: IgG2a
Antibody Clonality: Monoclonal
Antibody Clone: [NIMR-5]
Regulatory Status: RUO
Target Species: Mouse
Application: Flow Cytometry
Shipping:
blue ice
Storage:
Store vial at -20˚C
Documents
Further Information
Additional Names:
T10, ADP-ribosyl cyclase, cyclic ADP-ribose hydrolase
Application Note:
CD38 Antibody [NIMR-5] for use in flow cytometry, immunohistochemistry, immunoprecipitation, activation, stimulation, and blocking assays.
Background:
Murine CD38, a type II transmembrane glycoprotein, is a bifunctional ectoenzyme capable of catabolizing nicotinamide adenine dinucleotide (NAD+) to cyclic ADP-ribose (cADPR) and then hydrolyzing cADPR to adenosine diphosphoribose (ADPR). It is expressed at high levels on the surface of peripheral B-lineage cells and at low density on germinal center B cells from unimmunized mice. It has also been reported to be expressed at moderate levels on NK cells, a proportion of peripheral T cells, and a subpopulation of thymocytes which are mostly TCRalphabeta+, CD4-, CD8-. Murine CD38 is also expressed by all Mac-1+ macrophages in the peritoneal cavities of unimmunized mice, but not by unstimulated bone-marrow-derived macrophages. Monoclonal antibodies to CD38 have been shown to induce B and T cell proliferation, protect B cells from apoptosis, and inhibit B lymphopoiesis.
Buffer:
Supplied in PBS
Concentration:
0.5 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
BCL1 plasma membrane glycoproteins
NCBI Gene ID #:
12494
NCBI Official Name:
CD38 antigen
NCBI Official Symbol:
Cd38
NCBI Organism:
Mus musculus
Physical State:
Liquid
Protein Accession #:
P56528
Research Area:
Cancer,Immunology,Obesity,Signal Transduction
SPECIFICITY:
CD38
Swissprot #:
P56528
User NOte:
Optimal dilutions for each application to be determined by the researcher.