IKKb Antibody [IKB355]
| Code | Size | Price |
|---|
| PSI-33-004-100ug | 100ug | £662.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Mouse
Antibody Isotype: IgG1, kappa
Antibody Clonality: Monoclonal
Antibody Clone: IKB355
Regulatory Status: RUO
Target Species:
- Human
- Mouse
Application: Western Blot (WB)
Shipping:
blue ice
Storage:
Aliquot and Store at -20C. Avoid freez-thaw cycles.
Documents
Further Information
Additional Names:
IKK beta Antibody: IKK2, IKKB, IMD15, NFKBIKB, IKK-beta, Inhibitor of nuclear factor kappa-B kinase subunit beta, I-kappa-B kinase 2, I-kappa-B-kinase beta
Application Note:
Western blot: 2-4 ug/ml
Provided assay concentrations are suggestions only, IKKb antibody titration may be required for optimal results.
Provided assay concentrations are suggestions only, IKKb antibody titration may be required for optimal results.
Background:
NF-kB is sequestered in the cytoplasm by IkBa, unable to translocate to the nucleus. IkB is part of the canonical pathway for NF-kB activation. IKKb is part of the IkB kinase complex, along with a second catalytic subunit, IKKa, and a regulatory subunit, IKKg. Along with IKKa, IKKb phosphorylates IkBa leading to its degradation and release of inhibition of NF-kB. The RELA subunit of active NF-kB is then free to enter the nucleus and initiate a number of signaling cascades.
Buffer:
PBS with 0.1 mg/ml BSA and 0.05% sodium azide
Concentration:
0.5 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
A recombinant protein fragment of IKKb was used as the immunogen for this antibody.
NCBI Gene ID #:
3551
NCBI Official Name:
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
NCBI Official Symbol:
IKBKB
NCBI Organism:
Homo sapiens
Physical State:
Liquid
Purification:
Protein G purified antibody
Research Area:
Signal Transduction
Swissprot #:
O14920
User NOte:
Optimal dilutions for each application to be determined by the researcher