OTUD5 Antibody

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ProSci
Product Code: PSI-33-033
Product Group: Primary Antibodies
Supplier: ProSci
CodeSizePrice
PSI-33-033-100ug100ug£662.00
Quantity:
Prices exclude any Taxes / VAT

Overview

Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
  • Human
  • Mouse
  • Rat
Application: Western Blot (WB)
Shipping:
blue ice
Storage:
Aliquot and Store at -20C. Avoid freez-thaw cycles.

Images

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Western blot testing of human samples with OTUD5 antibody at 2ug/ml.
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Western blot testing of human samples with OTUD5 antibody at 2ug/ml.

Documents

Further Information

Additional Names:
OTUD5 Antibody: DUBA, OTU domain-containing protein 5, Deubiquitinating enzyme A, DUBA
Application Note:
Western blot: 2-5 ug/ml

Provided assay concentrations are suggestions only, antibody titration may be required for optimal results.
Background:
OTUD5 (ovarian tumor domain-containing 5), also called DUBA (Deubiquitinating enzyme A), is a product of the OTUD5 gene, and a suppressor of the innate immune response via its deubiquitinating activity. The Innate immune systems provide immediate but short-lived defense against infection identified by PRRs, or pattern recognition receptors. OTUD5 cleaves the lysine-63-linked polyubiquitin chains of TRAF3, causing it to dissociate from TBK1, thereby failing to stimulate IFN type 1 production and leading to a suppressed innate immune response.
Buffer:
PBS with 0.1 mg/ml BSA and 0.05% sodium azide
Concentration:
0.5 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
A recombinant protein fragment from the C-terminal region of human OTUD5 was used as the immunogen for this antibody.
NCBI Gene ID #:
55593
NCBI Official Name:
OTU domain containing 5
NCBI Official Symbol:
OTUD5
NCBI Organism:
Homo sapiens
Physical State:
Liquid
Purification:
Protein A affinity chromatography
Research Area:
Innate Immunity
Swissprot #:
Q96G74
User NOte:
Optimal dilutions for each application to be determined by the researcher