PAX8 Antibody [PAX8/1491]

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ProSci
Product Code: PSI-33-765
Product Group: Primary Antibodies
Supplier: ProSci
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PSI-33-765-100ug100ug£765.00
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Overview

Host Type: Mouse
Antibody Isotype: IgG2b
Antibody Clonality: Monoclonal
Antibody Clone: PAX8/1491
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Shipping:
blue ice
Storage:
Aliquot and Store at -20C. Avoid freez-thaw cycles.

Images

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Western blot testing of 1) human partial recombinant protein and 2) human Raji cell lysate with PAX-8 antibody (clone PAX8/1491). Predicted molecular weight of isoforms 1-5: 31, 35, 42, 43 and 48 kDa, respectively. PAX-8 can also be observed at ~62 kDa.
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Western blot testing of 1) human partial recombinant protein and 2) human Raji cell lysate with PAX-8 antibody (clone PAX8/1491). Predicted molecular weight of isoforms 1-5: 31, 35, 42, 43 and 48 kDa, respectively. PAX-8 can also be observed at ~62 kDa.

Documents

Further Information

Additional Names:
Paired box protein Pax-8, PAX8
Application Note:
WB: 0.5-1 ug/ml

Optimal dilution of the PAX-8 antibody should be determined by the researcher.
Background:
PAX-8 is a member of the paired box (PAX) family of transcription factors. This nuclear protein is involved in thyroid follicular cell development and expression of thyroid-specific genes. Mutations in this gene have been associated with thyroid dysgenesis, thyroid follicular carcinomas, and atypical thyroid adenomas. PAX-8 is expressed in the thyroid (and associated carcinomas), non-ciliated mucosal cells of the fallopian tubes, and simple ovarian inclusion cysts, but not normal ovarian surface epithelial cells. PAX-8 is expressed in a high percentage of ovarian serous, endometrioid, and clear cell carcinomas, but only rarely in primary ovarian mucinous adenocarcinomas. PAX-8 expression is reported in renal tubules as well as renal cell carcinoma, nephroblastoma, and seminoma. PAX-8 antibody may be used as an additional immunohistochemical marker for renal epithelial tumors.
Buffer:
PBS with 0.1 mg/ml BSA and 0.05% sodium azide
Concentration:
0.2 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
A human recombinant fragment (aa 60-261) was used as the immunogen for the PAX-8 antibody.
NCBI Gene ID #:
7849
NCBI Official Name:
paired box 8
NCBI Official Symbol:
PAX8
NCBI Organism:
Homo sapiens
Physical State:
Liquid
Purification:
Protein G affinity chromatography
Research Area:
Neuroscience
Swissprot #:
Q06710
User NOte:
Optimal dilutions for each application to be determined by the researcher