Gamma Catenin Antibody [15F11]
| Code | Size | Price |
|---|
| PSI-33-586-100ug | 100ug | £765.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Mouse
Antibody Isotype: IgG1, kappa
Antibody Clonality: Monoclonal
Antibody Clone: 15F11
Regulatory Status: RUO
Target Species:
- Bovine (Cattle)
- Chicken (Gallus)
- Feline (cat)
- Human
- Mouse
- Rat
Applications:
- Immunofluorescence (IF)
- Immunoprecipitation (IP)
- Western Blot (WB)
Shipping:
blue ice
Storage:
Aliquot and Store at -20C. Avoid freez-thaw cycles.
Documents
Further Information
Additional Names:
Junction plakoglobin, Catenin gamma, Desmoplakin III, Desmoplakin-3, JUP, CTNNG, DP3
Application Note:
Immunofluorescence: 1-2 ug/ml
WB: 0.5-1 ug/ml
Immunoprecipitation: suitable
The stated application concentrations are suggested starting amounts. Titration of the Plakoglobin antibody may be required due to differences in protocols and secondary/substrate sensitivity.
WB: 0.5-1 ug/ml
Immunoprecipitation: suitable
The stated application concentrations are suggested starting amounts. Titration of the Plakoglobin antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Background:
Plakoglobin, or gamma Catenin, is a common junctional plaque protein. The membrane-associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of Plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques. Acts as a substrate for VE-PTP and is required by it to stimulate VE-cadherin function in endothelial cells. Can replace beta-catenin in E-cadherin/catenin adhesion complexes which are proposed to couple cadherins to the actin cytoskeleton (By similarity). [UniProt]
Buffer:
PBS with 0.1 mg/ml BSA and 0.05% sodium azide
Concentration:
0.2 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
Recombinant full length chicken gamma Catenin was used as the immunogen for the Plakoglobin antibody.
NCBI Gene ID #:
3728
NCBI Official Name:
junction plakoglobin
NCBI Official Symbol:
JUP
NCBI Organism:
Homo sapiens
Physical State:
Liquid
Purification:
Protein G affinity chromatography
Research Area:
Signal Transduction
Swissprot #:
P14923
User NOte:
Optimal dilutions for each application to be determined by the researcher