Integrin beta 3 Antibody [ITGB3/1713]
| Code | Size | Price |
|---|
| PSI-33-635-100ug | 100ug | £765.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Mouse
Antibody Isotype: IgG1, kappa
Antibody Clonality: Monoclonal
Antibody Clone: ITGB3/1713
Regulatory Status: RUO
Target Species: Human
Applications:
- Immunofluorescence (IF)
- Immunohistochemistry- Frozen Section (IHC-F)
- Immunohistochemistry- Paraffin Embedded (IHC-P)
Shipping:
blue ice
Storage:
Aliquot and Store at -20C. Avoid freez-thaw cycles.
Documents
Further Information
Additional Names:
Integrin beta-3, Platelet membrane glycoprotein IIIa, GPIIIa, CD61, ITGB3, GP3A
Application Note:
Flow Cytometry: 0.5-1 ug/million cells in 0.1ml
Immunofluorescence: 0.5-1 ug/ml
IHC (FFPE & Frozen): 1-2 ug/ml for 30 min at RT
Titration of the Integrin beta 3 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Immunofluorescence: 0.5-1 ug/ml
IHC (FFPE & Frozen): 1-2 ug/ml for 30 min at RT
Titration of the Integrin beta 3 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Background:
Reacts with human Integrin beta 3, also called CD61. It associates with the alphaV-chain (CD51) to form vitronectin receptor, or with the alphaIIb-chain (CD41) to form the GpIIb/GpIIIa complex (CD41/CD61). The CD41/CD61 complex appears early in megakaryocyte maturation. The activated CD41/CD61 complex is a receptor for von Willebrand factor, soluble fibrinogen, fibronectin, vitronectin and thrombospondin. It plays a central role in platelet activation and aggregation. The CD51/CD61 is implicated in tumor metastasis and adenoviral infection. The antibody detects platelets in smears of blood and bone marrow, as well as megakaryocytes in frozen sections and cell smears. The antibody is useful for classification of megakaryoblastic leukemia.
Buffer:
PBS with 0.1 mg/ml BSA and 0.05% sodium azide
Concentration:
0.2 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
Human recombinant protein used as the immunogen for the Integrin beta 3 antibody.
NCBI Gene ID #:
3690
NCBI Official Name:
integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
NCBI Official Symbol:
ITGB3
NCBI Organism:
Homo sapiens
Physical State:
Liquid
Purification:
Protein G affinity
Research Area:
Cancer,Immunology,Signal Transduction
Swissprot #:
P05106
User NOte:
Optimal dilutions for each application to be determined by the researcher