TAB3 Antibody

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ProSci
Product Code: PSI-33-061
Product Group: Primary Antibodies
Supplier: ProSci
CodeSizePrice
PSI-33-061-100ug100ug£662.00
Quantity:
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Overview

Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
  • Human
  • Mouse
Application: Western Blot (WB)
Shipping:
blue ice
Storage:
Aliquot and Store at -20C. Avoid freez-thaw cycles.

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Western blot testing of human samples with TAB3 antibody at 4ug/ml.
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Western blot testing of human samples with TAB3 antibody at 4ug/ml.

Documents

Further Information

Additional Names:
TAB3 Antibody: NAP1, MAP3K7IP3, TGF-beta-activated kinase 1 and MAP3K7-binding protein 3, Mitogen-activated protein kinase kinase kinase 7-interacting protein 3, TAB-3
Application Note:
Western blot: 4-8 ug/ml

Provided assay concentrations are suggestions only, antibody titration may be required for optimal results.
Background:
TAB3, a TAB2-like protein, is a mediator of TAK1 activation in IL-1 and TNF signaling. IL-1 and TNF are cytokines involved in the inflammation process, initiating signaling cascades leading to the activation of NF-kB and mitogen-activated protein kinases (MAPKs). TAB3 functions as an adapter, linking TAK1 and TRAF6 or TRAF2. This kinase complex phosphorylates IkB, which keeps NF-kB inactive and sequestered in the cytoplasm. Phosphorylation leads to IkB degradation, activating NF-kB, which translocates to the nucleus, binds to DNA response elements and can begin multiple signaling cascades.
Buffer:
PBS with 0.1 mg/ml BSA and 0.05% sodium azide
Concentration:
0.5 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
A recombinant protein fragment from the N-terminal region of human TAB3 was used as the immunogen for this antibody.
NCBI Gene ID #:
257397
NCBI Official Name:
TGF-beta activated kinase 1/MAP3K7 binding protein 3
NCBI Official Symbol:
TAB3
NCBI Organism:
Homo sapiens
Physical State:
Liquid
Purification:
Protein A purified antibody
Research Area:
Autophagy
Swissprot #:
Q8N5C8
User NOte:
Optimal dilutions for each application to be determined by the researcher