H-2Kd/H-2Dd Antibody [34-1-2S] (PE)
| Code | Size | Price |
|---|
| PSI-99-079-0.1mg | 0.1mg | £524.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Mouse
Antibody Isotype: IgG2a
Antibody Clonality: Monoclonal
Antibody Clone: [34-1-2S]
Regulatory Status: RUO
Target Species: Mouse
Applications:
- Immunohistochemistry- Frozen Section (IHC-F)
- Immunoprecipitation (IP)
Shipping:
blue ice
Storage:
Store vial at 2-8˚C
Documents
Further Information
Additional Names:
MHC Class I
Application Note:
H-2Kd/H-2Dd Antibody [34-1-2S] for use in flow cytometry assays.
Background:
The ?classical? MHC Class I molecules are histocompatibility antigens encoded by the H-2 gene complex and consist of heterodimers of highly polymorphic alpha chains noncovalently associated with the invariant beta2-microglobulin. These antigens are expressed on most nucleated cells but expression varies on different cell types. MHC Class I molecules present endogenously synthesized peptides to CD8+ T lymphocytes, which are usually cytotoxic T cells. MHC Class I antigens expressed on thymic epithelial cells regulate the positive and negative selection of CD8+ T cells during T cell ontogeny. The monoclonal antibody 34-1-2S binds to a common determinant in the alpha3 domains of H-2Kd and H-2Dd in the presence or absence of beta2 microglobulin. It cross reacts with the alpha3 domain of H-2Kb.
Buffer:
Supplied in PBS/NaN3 and a stabilizing agent
Concentration:
0.1 mg/mL
Conjugate:
PE
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
BDF1 mouse splenocytes
NCBI Gene ID #:
14964/14972
NCBI Official Name:
histocompatibility 2, D region locus 1; histocompatibility 2, K1, K region
NCBI Official Symbol:
H2-D1; H2-K1
NCBI Organism:
Mus musculus
Physical State:
Liquid
Research Area:
Immunology
SPECIFICITY:
H-2Kd/H-2Dd
User NOte:
Optimal dilutions for each application to be determined by the researcher.