CD117 Antibody [2B8] (APC-Cy5.5)
| Code | Size | Price |
|---|
| PSI-99-021-0.1mg | 0.1mg | £560.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rat
Antibody Isotype: IgG2b
Antibody Clonality: Monoclonal
Antibody Clone: [2B8]
Regulatory Status: RUO
Target Species: Mouse
Application: Flow Cytometry
Shipping:
blue ice
Storage:
Store vial at 2-8˚C
Documents
Further Information
Additional Names:
c-Kit, mast cell growth factor, stem cell factor, steel factor, SCF
Application Note:
CD117 Antibody [2B8] for use in flow cytometry assays.
Background:
The CD117 (c-Kit) antigen is the cell-surface receptor for stem cell factor (SCF). Together these molecules constitute a ligand/receptor pair which functions to maintain normal hematopoiesis in the adult. Signaling through SCF/c-Kit has an important role in stimulating myeloid and erythroid production of primitive hematopoietic progenitor cells. A variety of cytokines act synergistically with SCF to stimulate proliferation and differentiation of bone marrow progenitor cells. For example, SCF plus IL-7 can stimulate the combined myeloid and B cell differentiation of uncommitted hematopoietic progenitor cells. SCF/c-Kit also participates in erythropoiesis in both the bone marrow and spleen. Loss-of-function mutations for SCF/c-Kit lead to a variety of pleiotropic developmental defects while gain-of-function mutations can lead to constitutive activation of the kit receptor and links to cancer. Examples of the former are mast cell deficiency and severe macrocytic anemia while the latter mutation has been identified in mastocytomas.
Buffer:
Supplied in PBS/NaN3 and a stabilizing agent
Concentration:
0.1 mg/mL
Conjugate:
APC-Cy5.5
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
Mouse IL-3-dependent bone marrow mast cells
NCBI Gene ID #:
16590
NCBI Official Name:
Mast/stem cell growth factor receptor Kit
NCBI Official Symbol:
Kit
NCBI Organism:
Mus musculus
Physical State:
Liquid
Protein Accession #:
P05532
Research Area:
Cancer,Cell Cycle,Immunology,Neuroscience,Signal Transduction
SPECIFICITY:
CD117
Swissprot #:
P05532
User NOte:
Optimal dilutions for each application to be determined by the researcher.