CD23 Antibody [2G8] (Biotin)
| Code | Size | Price |
|---|
| PSI-98-685-0.5mg | 0.5mg | £560.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rat
Antibody Isotype: IgG2a
Antibody Clonality: Monoclonal
Antibody Clone: [2G8]
Regulatory Status: RUO
Target Species: Mouse
Application: Flow Cytometry
Shipping:
blue ice
Storage:
Store vial at 2-8˚C
Documents
Further Information
Additional Names:
FcepsilonRII, BLAST-2, low affinity IgE receptor, Ly-42
Application Note:
CD23 Antibody [2G8] for use in flow cytometry, ELISA, and immunohistochemistry assays.
Background:
The CD23 antigen is the low affinity IgE Fc receptor, which is a 45-49 kDa protein with 38 and 28 kDa fragments. It is expressed on most mature, conventional B cells (but not on peritoneal CD5+ B cells) and can also be found on the surface of T cells, macrophages and platelets. It is distinct from the high affinity IgE receptors found on basophils and mast cells which mediate allergic reactions. The low affinity receptors are thought to play a role in isotype specific immunoregulation. The regulation of CD23 surface expression appears to be integral with the complex IgE system which involves interactions of cells, cytokines, antibodies and regulatory factors. CD23 has been described as a ?membrane bound cytokine," in that the soluble cleavage products of CD23 are themselves able to act as cytokines in vitro.
Buffer:
Supplied in PBS/NaN3
Concentration:
0.5 mg/mL
Conjugate:
Biotin
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
FcepsilonR isolated from B cell lymphoma cell line M12.4.5
NCBI Gene ID #:
14128
NCBI Official Name:
Fc receptor, IgE, low affinity II, alpha polypeptide
NCBI Official Symbol:
Fcer2a
NCBI Organism:
Mus musculus
Physical State:
Liquid
Protein Accession #:
P20693
Research Area:
Immunology,Stem Cell,Cancer,Cell Cycle
SPECIFICITY:
CD23
Swissprot #:
P20693
User NOte:
Optimal dilutions for each application to be determined by the researcher.