CD45.1 Antibody [A20] (APC)
| Code | Size | Price |
|---|
| PSI-98-917-0.1mg | 0.1mg | £560.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Mouse
Antibody Isotype: IgG2a
Antibody Clonality: Monoclonal
Antibody Clone: [A20]
Regulatory Status: RUO
Target Species: Mouse
Applications:
- Immunocytochemistry (ICC)
- Immunohistochemistry- Frozen Section (IHC-F)
- Western Blot (WB)
Shipping:
blue ice
Storage:
Store vial at 2-8˚C
Documents
Further Information
Additional Names:
Ly-5.1, LCA, SJL, T200
Application Note:
CD45.1 Antibody [A20] for use in flow cytometry assays.
Background:
The CD45 antigen is an essential regulator of leukocyte activation and development and is now known to be a protein tyrosine phosphatase, e.g., CD45 is able to dephosphorylate the Src family of protein kinases. This activity is now known to be required for signal transduction induced by T and B cell antigen receptor engagement, cytokine signaling, and Fc receptor stimulation. The functional state of CD45 also has a pronounced effect on lymphocyte development. CD45 exists in multiple forms, such as the restricted variants (CD45R; see companion products 1660, 1665, 1675, 1685, and 1820) and as allelic forms CD45.1 (Ly-5.1) and CD45.2 (Ly-5.2). The former arises as a result of alternative splicing of different exons. The specificity of antibodies to CD45.1 and CD45.2 has been exploited in studies where resolution of donor and recipient cells is essential, such as in gene therapy or bone marrow transplantation. The monoclonal antibody A20 recognizes all mouse leukocytes expressing the CD45.1 allotype.
Buffer:
Supplied in PBS/NaN3 and a stabilizing agent
Concentration:
0.1 mg/mL
Conjugate:
APC
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
SJL mouse thymocytes and splenocytes
NCBI Gene ID #:
19264
NCBI Official Name:
protein tyrosine phosphatase, receptor type, C
NCBI Official Symbol:
Ptprc
NCBI Organism:
Mus musculus
Physical State:
Liquid
Protein Accession #:
P06800
Research Area:
Immunology
SPECIFICITY:
CD45.1
Swissprot #:
P06800
User NOte:
Optimal dilutions for each application to be determined by the researcher.