BiP Antibody [76-E6] (Biotin)
| Code | Size | Price |
|---|
| PSI-98-891-0.5mg | 0.5mg | £686.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rat
Antibody Isotype: IgG2a
Antibody Clonality: Monoclonal
Antibody Clone: [76-E6]
Regulatory Status: RUO
Target Species: Mouse
Application: Flow Cytometry
Shipping:
blue ice
Storage:
Store vial at 2-8˚C
Documents
Further Information
Additional Names:
GRP78
Application Note:
BiP Antibody [76-E6] for use in ELISA, western blotting, and immunoprecipitation assays.
Background:
The immunoglobulin heavy chain binding protein BiP is a member of the hsp70 family of heat shock proteins and is identical to the glucose regulated protein GRP78. While BiP was originally described for its function in B cells, it is now known to be distributed in a variety of tissues, if not ubiquitous. The highly conserved hsp70 proteins have an essential physiological role in stress responses and as ?molecular chaperones? which are responsible for a variety of functions such as protein transport, prevention of protein toxicity and direction of protein folding. With regard to its immunological role, BiP is a component of the endoplasmic reticulum and binds free intracellular heavy chains in nonsecreting pre-B cell lines (?+,L-) or incompletely assembled Ig precursors in H+L+ secreting hybridomas and myelomas. In the absence of light chain synthesis, heavy chains remain associated with BiP and are not secreted. BiP is an ATP binding protein and the dissociation of the BiP-heavy chain complex is probably driven by the ATPase activity attributed to BiP. The monoclonal antibody 76-E6 recognizes a conserved epitope localized within the region of amino acids 497 to 581 of BiP.
Buffer:
Supplied in PBS/NaN3
Concentration:
0.5 mg/mL
Conjugate:
Biotin
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
Mouse BiP:µ chain complexes
NCBI Gene ID #:
14828
NCBI Official Name:
Fc receptor, IgE, low affinity II, alpha polypeptide
NCBI Official Symbol:
Fcer2a
NCBI Organism:
Mus musculus
Physical State:
Liquid
Protein Accession #:
P20693
Research Area:
Other
SPECIFICITY:
BiP
Swissprot #:
P20693
User NOte:
Optimal dilutions for each application to be determined by the researcher.