KLRG1 Antibody [2F1]
| Code | Size | Price |
|---|
| PSI-98-965-0.5mg | 0.5mg | £560.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Hamster
Antibody Isotype: IgG
Antibody Clonality: Monoclonal
Antibody Clone: [2F1]
Regulatory Status: RUO
Target Species:
- Human
- Mouse
Application: Immunohistochemistry- Frozen Section (IHC-F)
Shipping:
blue ice
Storage:
Store vial at 2-8˚C
Documents
Further Information
Additional Names:
MAFA, killer cell lectin-like receptor G1, mast cell function-associated-antigen
Application Note:
KLRG1 Antibody [2F1] for use in flow cytometry, western blotting, and immunoprecipitation assays.
Background:
The monoclonal antibody 2F1 reacts with mouse killer cell lectin-like receptor G1 (KLRG1; formerly known as mouse MAFA), a homodimeric member of the lectin-like type 2 transmembrane receptor family that contain characteristic immunoreceptor tyrosine-based inhibitory motifs (ITIMs) in their cytoplasmic domains. These ITIMs interact with the SH2 domains of protein phosphatases such as SHP-1. The 2F1 antibody stains 30-60% of NK1.1+CD3- splenocytes, and a small fraction of T cells in all mouse strains tested (C57BL/6, BALB/c, 129/J, C3H.SW, AKR/J, SJL). Cell surface expression of KLRG1 is up-regulated by expression of MHC class I molecules. The effect of MHC class I expression is indirect, and can be mediated by interactions with class I-specific Ly49 inhibitory receptors.
Buffer:
Supplied in borate buffered saline, pH 8.2; No preservatives or amine-containing buffer salts added
Concentration:
0.5 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
IL-2-activated NK cells (A-LAK cells) from B6 (H-2b) mice
NCBI Gene ID #:
50928
NCBI Official Name:
killer cell lectin-like receptor subfamily G, member 1
NCBI Official Symbol:
Klrg1
NCBI Organism:
Mus musculus
Physical State:
Liquid
Protein Accession #:
O88713
Research Area:
Innate Immunity,Immunology
SPECIFICITY:
KLRG1
Swissprot #:
O88713
User NOte:
Optimal dilutions for each application to be determined by the researcher.