KLRG1 Antibody [2F1] (PE)

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ProSci
Product Code: PSI-98-968
Product Group: Primary Antibodies
Supplier: ProSci
CodeSizePrice
PSI-98-968-0.1mg0.1mg£597.00
Quantity:
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Overview

Host Type: Hamster
Antibody Isotype: IgG
Antibody Clonality: Monoclonal
Antibody Clone: [2F1]
Regulatory Status: RUO
Target Species:
  • Human
  • Mouse
Application: Flow Cytometry
Shipping:
blue ice
Storage:
Store vial at 2-8˚C

Images

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C57BL/6 mouse splenocytes were stained with Hamster Anti-Mouse KLRG1-PE (Cat. No. 98-968), Mouse Anti-Mouse NK1.1-FITC , and Rat Anti-Mouse CD3-SPRD .
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C57BL/6 mouse splenocytes were stained with Hamster Anti-Mouse KLRG1-PE (Cat. No. 98-968), Mouse Anti-Mouse NK1.1-FITC , and Rat Anti-Mouse CD3-SPRD .

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Further Information

Additional Names:
MAFA, killer cell lectin-like receptor G1, mast cell function-associated-antigen
Application Note:
KLRG1 Antibody [2F1] for use in flow cytometry assays.
Background:
The monoclonal antibody 2F1 reacts with mouse killer cell lectin-like receptor G1 (KLRG1; formerly known as mouse MAFA), a homodimeric member of the lectin-like type 2 transmembrane receptor family that contain characteristic immunoreceptor tyrosine-based inhibitory motifs (ITIMs) in their cytoplasmic domains. These ITIMs interact with the SH2 domains of protein phosphatases such as SHP-1. The 2F1 antibody stains 30-60% of NK1.1+CD3- splenocytes, and a small fraction of T cells in all mouse strains tested (C57BL/6, BALB/c, 129/J, C3H.SW, AKR/J, SJL). Cell surface expression of KLRG1 is up-regulated by expression of MHC class I molecules. The effect of MHC class I expression is indirect, and can be mediated by interactions with class I-specific Ly49 inhibitory receptors.
Buffer:
Supplied in PBS/NaN3 and a stabilizing agent
Concentration:
0.1 mg/mL
Conjugate:
PE
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
IL-2-activated NK cells (A-LAK cells) from B6 (H-2b) mice
NCBI Gene ID #:
50928
NCBI Official Name:
killer cell lectin-like receptor subfamily G, member 1
NCBI Official Symbol:
Klrg1
NCBI Organism:
Mus musculus
Physical State:
Liquid
Protein Accession #:
O88713
Research Area:
Innate Immunity,Immunology
SPECIFICITY:
KLRG1
Swissprot #:
O88713
User NOte:
Optimal dilutions for each application to be determined by the researcher.