TGF-beta Antibody [1D11.16.8]

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ProSci
Product Code: PSI-33-469
Product Group: Primary Antibodies
Supplier: ProSci
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PSI-33-469-100ug100ug£765.00
Quantity:
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Overview

Host Type: Mouse
Antibody Isotype: IgG1, kappa
Antibody Clonality: Monoclonal
Antibody Clone: 1D11.16.8
Regulatory Status: RUO
Target Species:
  • Bovine (Cattle)
  • Hamster
  • Human
  • Monkey
  • Mouse
  • Rat
Shipping:
blue ice
Storage:
Aliquot and Store at -20C. Avoid freez-thaw cycles.

Images

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IHC staining of FFPE human salivary gland carcinoma with TGF-beta antibody. HIER: boil tissue sections in pH6, 10mM citrate buffer, for 10-20 min and allow to cool before testing.
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IHC staining of FFPE human salivary gland carcinoma with TGF-beta antibody. HIER: boil tissue sections in pH6, 10mM citrate buffer, for 10-20 min and allow to cool before testing.

Documents

Further Information

Application Note:
Functional Activity: Cytokine Neutralization (Order SAF formulation)

Optimal dilution of the TGF-beta antibody should be determined by the researcher.
Background:
This mAb recognizes TGF beta 1, 2 and 3. Three TGFbs have been identified in mammals. TGFb1, TGFb2 and TGFb3 are each synthesized as precursor proteins that are very similar in that each is cleaved to yield a 112 amino acid polypeptide that remains associated with the latent portion of the molecules. Biologically active TGFb requires dimerization of the monomers (usually homodimers) and release of the latent peptide portion. Overall, the mature region of the TGFb3 protein has approximately 80% identity to the mature region of both TGFb1 and TGFb2. However, the NH2 terminals or precursor regions of their molecules share only 27% sequence identity. TGFb's inhibit the growth of epithelial cells and stimulate the growth of mesenchymal cells.
Buffer:
PBS with 0.1 mg/ml BSA and 0.05% sodium azide
Concentration:
0.2 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
Bovine TGF-beta2 protein was used as the immunogen for the TGF-beta antibody.
NCBI Gene ID #:
7040, 7043, 7042
NCBI Official Name:
transforming growth factor beta 1, transforming growth factor beta 3, transforming growth factor beta 2
NCBI Official Symbol:
TGFB1, TGFB3, TGFB2
NCBI Organism:
Homo sapiens
Physical State:
Liquid
Purification:
Protein G affinity chromatography
Research Area:
Cancer, Signal Transduction, Obesity, Stem Cell
Swissprot #:
P01137, P10600, P61812
User NOte:
Optimal dilutions for each application to be determined by the researcher