CD49d Antibody [PS/2] (Biotin)
| Code | Size | Price |
|---|
| PSI-98-551-0.5mg | 0.5mg | £560.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rat
Antibody Isotype: IgG2b
Antibody Clonality: Monoclonal
Antibody Clone: [PS/2]
Regulatory Status: RUO
Target Species:
- Human
- Mouse
Application: Flow Cytometry
Shipping:
blue ice
Storage:
Store vial at 2-8˚C
Documents
Further Information
Additional Names:
Integrin alpha4, VLA-4alpha, ITGA4, IA4
Application Note:
CD49d Antibody [PS/2] for use in flow cytometry, immunohistochemistry, and immunoprecipitation assays.
Background:
VLA-4 belongs to the beta1-integrin family, which functions both as cell-matrix and cell-cell receptors. As a matrix receptor VLA-4 binds to an alternatively spliced domain of fibronectin, while as a cellular receptor it associates with its counter-receptor ligand VCAM-1. In addition to CD44/Pgp-1, VLA-4 has been shown to be important for lymphopoiesis, and is also believed to be important for extravasation of lymphocytes into sites of inflammation as a second signal in addition to LFA/ICAM-1. CD49d is expressed in low amounts on resting lymphocytes and monocytes, is absent or minimally detectable on stromal cells, whereas virtually all lymphoid and myeloid cells in bone marrow and in long-term culture are positive. Antibody PS/2 also reacts with human VLA-4.
Buffer:
Supplied in PBS/NaN3
Concentration:
0.5 mg/mL
Conjugate:
Biotin
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
P815 cells
NCBI Gene ID #:
16401
NCBI Official Name:
integrin alpha 4
NCBI Official Symbol:
Itga4
NCBI Organism:
Mus musculus
Physical State:
Liquid
Protein Accession #:
Q00651
Research Area:
Immunology
SPECIFICITY:
CD49d
Swissprot #:
Q00651
User NOte:
Optimal dilutions for each application to be determined by the researcher.