KBU2046
| Code | Size | Price |
|---|
| AG-CR1-0159-M001 | 1 mg | £70.00 |
Quantity:
| AG-CR1-0159-M005 | 5 mg | £160.00 |
Quantity:
| AG-CR1-0159-M025 | 25 mg | £385.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
Ambient
Storage:
+4°C
Documents
Further Information
Alternate Names/Synonyms:
3-(4-Fluorophenyl)-chroman-4-one
Appearance:
White to off-white solid.
CAS:
1143863-69-7
EClass:
32160000
Form (Short):
liquid
Handling Advice:
Keep cool and dry.
InChi:
InChI=1S/C15H11FO2/c16-11-7-5-10(6-8-11)13-9-18-14-4-2-1-3-12(14)15(13)17/h1-8,13H,9H2
InChiKey:
XKAFGKFIJBGYAP-UHFFFAOYSA-N
Long Description:
Chemical. CAS: 1143863-69-7. Formula: C15H11FO2. MW: 242.2. Highly selective metastasis inhibitor in vitro. Binds to and stabilizes Cdc37-HSP90beta heterocomplexes, consequently blocking its function and inhibiting cancer cell motility. Does not bind to Cdc37 or HSP90beta alone. Inhibits cancer metastasis in vivo in murine models of human prostate and breast cancer. Shown to exhibit a complete lack of cellular cytotoxicity and systemic toxicity.
MDL:
MFCD28970009
Molecular Formula:
C15H11FO2
Molecular Weight:
242.2
Package Type:
Vial
Product Description:
Highly selective metastasis inhibitor in vitro. Binds to and stabilizes Cdc37-HSP90beta heterocomplexes, consequently blocking its function and inhibiting cancer cell motility. Does not bind to Cdc37 or HSP90beta alone. Inhibits cancer metastasis in vivo in murine models of human prostate and breast cancer. Shown to exhibit a complete lack of cellular cytotoxicity and systemic toxicity.
Purity:
>98% (HPLC)
SMILES:
O=C1C(C2=CC=C(F)C=C2)COC3=CC=CC=C31
Solubility Chemicals:
Soluble in DMSO, ethanol, methanol or DCM. Insoluble in water.
Transportation:
Non-hazardous
UNSPSC Category:
Biochemical Reagents
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at -20°C.
References
Precision therapeutic targeting of human cancer cell motility: L. Xu, et al.; Nat. Commun. 9, 2454 (2018)
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