Sibiriline
| Code | Size | Price |
|---|
| AG-CR1-0160-M005 | 5 mg | £80.00 |
Quantity:
| AG-CR1-0160-M025 | 25 mg | £220.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
Ambient
Storage:
+4°C
Documents
Further Information
Alternate Names/Synonyms:
4-(1H-Pyrrolo[2,3-b]pyridin-2-yl)phenol
Appearance:
Off-white to tan solid.
CAS:
1346526-26-8
EClass:
32160000
Form (Short):
liquid
Handling Advice:
Keep cool and dry.
InChi:
InChI=1S/C13H10N2O/c16-11-5-3-9(4-6-11)12-8-10-2-1-7-14-13(10)15-12/h1-8,16H,(H,14,15)
InChiKey:
XZQLYCMLGSOHOX-UHFFFAOYSA-N
Long Description:
Chemical. CAS: 1346526-26-8. Formula: C13H10N2O. MW: 210.2. Specific competitive RIPK1 inhibitor in vitro (IC50=1.03µM). Binds to human RIPK1 adenosine triphosphate-binding site and locks it in an inactive conformation to block necroptosis. Necroptosis contributes to the pathogenesis of several inflammatory diseases including ischemic reperfusion injury, acute pancreatitis, sepsis, neurodegeneration, viral infection and liver diseases. Inhibits both TNF-induced RIPK1-dependent necroptosis and RIPK1-dependent apoptosis in FADD-deficient Jurkat cells (EC50=1.2µM). Does not block caspase-dependent apoptosis induced by TRAIL, FasL or staurosporine. Protects mice from concanavalin A-induced hepatitis in vivo.
MDL:
MFCD22384233
Molecular Formula:
C13H10N2O
Molecular Weight:
210.2
Package Type:
Vial
Product Description:
Specific competitive RIPK1 inhibitor in vitro (IC50=1.03µM). Binds to human RIPK1 adenosine triphosphate-binding site and locks it in an inactive conformation to block necroptosis. Necroptosis contributes to the pathogenesis of several inflammatory diseases including ischemic reperfusion injury, acute pancreatitis, sepsis, neurodegeneration, viral infection and liver diseases. Inhibits both TNF-induced RIPK1-dependent necroptosis and RIPK1-dependent apoptosis in FADD-deficient Jurkat cells (EC50=1.2µM). Does not block caspase-dependent apoptosis induced by TRAIL, FasL or staurosporine. Protects mice from concanavalin A-induced hepatitis in vivo.
Purity:
>98% (HPLC)
SMILES:
OC(C=C1)=CC=C1C2=CC3=CC=CN=C3N2
Solubility Chemicals:
Soluble in DMSO (2mg/ml), ethanol or methanol. Insoluble in water.
Transportation:
Non-hazardous
UNSPSC Category:
Biochemical Reagents
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at -20°C.
References
Sibiriline, a new small chemical inhibitor of receptor-interacting protein kinase 1, prevents immune-dependent hepatitis: F. Le Cann, et al.; FEBS J. 284, 3050 (2017)
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