CD244(2B4) (human)-muIg Fusion Protein

2B4; SLAMF4

0.5mg/ml

32160000

liquid

50mM Sodium Phosphate pH 7.5, 100mM Potassium Chloride, 150mM NaCl, 0.5mg/ml Gentamicin sulfate.

Avoid freeze/thaw cycles.

Recombinant protein. Source/Host: CHO cells. Purity: . 50mM Sodium Phosphate pH 7.5, 100mM Potassium Chloride, 150mM NaCl, 0.5mg/ml Gentamicin sulfate. CD244 (2B4, SLAMF4) is a 66 kD member of the CD2/SLAM related receptor family (SRR). It is expressed on NK, T cell subsets, monocytes and eosinophils. It is expressed at high levels on Leuikemia initiating cells, and plays a role in their proliferative potential. In mice there are two transcription varients, a long form and a short form of CD244 each of which have distinct signaling properties. In humans, only the long form is expressed. Decreased CD244 expression on monocytes of SLE patients correlated (negatively) with autoantibody titers. CD244 mediated function in immune response can vary greatly dependant on the context of its ligation.

~135kDa (native dimer)

Plastic Vial

CD244 (2B4, SLAMF4) is a 66 kD member of the CD2/SLAM related receptor family (SRR). It is expressed on NK, T cell subsets, monocytes and eosinophils. It is expressed at high levels on Leuikemia initiating cells, and plays a role in their proliferative potential. In mice there are two transcription varients, a long form and a short form of CD244 each of which have distinct signaling properties. In humans, only the long form is expressed. Decreased CD244 expression on monocytes of SLE patients correlated (negatively) with autoantibody titers. CD244 mediated function in immune response can vary greatly dependant on the context of its ligation.

CHO cells

Binds to recombinant CD48 in EIA and cell surface CD48 on Raji cell surface in FACS.

Fc

Non-hazardous

Other Proteins

12352202

Stable for at least 6 months after receipt when stored at +4°C.