Articaine hydrochloride
| Code | Size | Price |
|---|
| CDX-A0564-M500 | 500 mg | £316.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
Ambient
Storage:
+4°C
Documents
Further Information
Alternate Names/Synonyms:
4-Methyl-3-[[1-oxo-2-(propylamino)propyl]amino]-2-thiophenecarboxylic acid methyl ester hydrochloride; Carticaine chlorhydrate; Carticaine hydrochloride; HOE 045; HOE 40045; Ultracaine
Appearance:
White to beige powder.
CAS:
23964-57-0
EClass:
32160000
Form (Short):
solid
GHS Symbol:
GHS07
Handling Advice:
Protect from light and moisture.
Hazards:
H315, H319, H335
InChi:
InChI=1S/C13H20N2O3S.ClH/c1-5-6-14-9(3)12(16)15-10-8(2)7-19-11(10)13(17)18-4;/h7,9,14H,5-6H2,1-4H3,(H,15,16);1H
InChiKey:
GDWDBGSWGNEMGJ-UHFFFAOYSA-N
Long Description:
Chemical. CAS: 23964-57-0. Formula: C13H20N2O3S . HCl. MW: 284.4 . 36.5. Synthetic. Articaine is an amide local anesthetic widely used in dentistry. It possesses a unique ester side chain that is metabolized rapidly by circulating esterases. Articaine blocks nerve conduction by reversibly binding to the alpha-subunit of the voltage-gated sodium channels within the inner cavity of the nerve, similar to other local anesthetics. Binding of articaine to the sodium channel reduces sodium influx so that the threshold potential will not be reached and impulse conduction stops. The blocking action of articaine on the sodium channel is state dependent.
MDL:
MFCD00190157
Molecular Formula:
C13H20N2O3S . HCl
Molecular Weight:
284.4 . 36.5
Package Type:
Vial
Precautions:
P305+P351+P338
Product Description:
Articaine is an amide local anesthetic widely used in dentistry. It possesses a unique ester side chain that is metabolized rapidly by circulating esterases. Articaine blocks nerve conduction by reversibly binding to the alpha-subunit of the voltage-gated sodium channels within the inner cavity of the nerve, similar to other local anesthetics. Binding of articaine to the sodium channel reduces sodium influx so that the threshold potential will not be reached and impulse conduction stops. The blocking action of articaine on the sodium channel is state dependent.
Purity:
>98% (HPLC)
Signal Word:
Warning
SMILES:
CC1=CSC(C(OC)=O)=C1NC(C(NCCC)C)=O.Cl
Solubility Chemicals:
Soluble in water (20 mg/ml), DMSO (15mg/ml) or ethanol (5mg/ml).
Source / Host:
Synthetic
Transportation:
Non-hazardous
UNSPSC Category:
Biochemical Reagents
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at -20°C.
References
(1) S.F. Malamed, et al.; J. Am. Dent. Assoc. 131, 635 (2000) | (2) G.K. Wang, et al.; J. Membr. Biol. 229, 1 (2009) | (3) M. Snoeck; Local Reg. Anesth. 5, 23 (2012) (Review)