Cinchocaine hydrochloride
| Code | Size | Price |
|---|
| CDX-C0693-G001 | 1 g | £41.00 |
Quantity:
| CDX-C0693-G005 | 5 g | £102.00 |
Quantity:
| CDX-C0693-G025 | 25 g | £285.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
Ambient
Storage:
+4°C
Documents
Further Information
Alternate Names/Synonyms:
Cinchocaine hydrochloride; 2-Butoxy-N-(2-diethylaminoethyl)-4-quinolinecarboxamide hydrochloride
Appearance:
White to off-white powder.
CAS:
61-12-1
EClass:
32160000
Form (Short):
liquid
GHS Symbol:
GHS05,GHS07
Handling Advice:
Protect from light and moisture.
Hazards:
H302, H318
InChi:
InChI=1S/C20H29N3O2.ClH/c1-4-7-14-25-19-15-17(16-10-8-9-11-18(16)22-19)20(24)21-12-13-23(5-2)6-3;/h8-11,15H,4-7,12-14H2,1-3H3,(H,21,24);1H
InChiKey:
IVHBBMHQKZBJEU-UHFFFAOYSA-N
Long Description:
Chemical. CAS: 61-12-1. Formula: C20H29N3O2 . HCl. MW: 343.4 . 36.5. Synthetic. Dibucaine is a long-acting local anesthetic. Potent Na+ channel blocker. It blocks both the initiation and conduction of nerve impulses by decreasing the neuronal membrane's permeability to sodium ions. This reversibly stabilizes the membrane and inhibits depolarization, resulting in the failure of a propagated action potential and subsequent conduction blockade. Induces apoptosis through calpain, cytochrome oxidase etc, and shows antiviral and antiparasitic activity.
MDL:
MFCD00012735
Molecular Formula:
C20H29N3O2 . HCl
Molecular Weight:
343.4 . 36.5
Package Type:
Vial
Precautions:
P280, P305+P351+P338
Product Description:
Dibucaine is a long-acting local anesthetic. Potent Na+ channel blocker. It blocks both the initiation and conduction of nerve impulses by decreasing the neuronal membrane's permeability to sodium ions. This reversibly stabilizes the membrane and inhibits depolarization, resulting in the failure of a propagated action potential and subsequent conduction blockade. Induces apoptosis through calpain, cytochrome oxidase etc, and shows antiviral and antiparasitic activity.
Purity:
>99% (HPLC)
Signal word:
Danger
SMILES:
O=C(NCCN(CC)CC)C1=CC(OCCCC)=NC2=CC=CC=C21.Cl
Solubility Chemicals:
Soluble in water (50mg/ml), DMSO (50mg/ml) or ethanol (50mg/ml).
Source / Host:
Synthetic
Transportation:
Non-hazardous
UNSPSC Category:
Biochemical Reagents
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at -20°C.
References
(1) G.R. Padmanabhan, et al.; Anal. Profiles Drug Subs. 12, 105 (1983) | (2) A Seelig; Biochim. Biophys. Acta 899, 196 (1987) | (3) E. Garcia-Martin & C. Gutierrez-Merino; J. Neurochem. 54, 1238 (1990) | (4) B.K. Stringer & H.J. Harmon; Biochem. Pharmacol. 40, 1077 (1990) | (5) A. Oda, et al.; Am. J. Physiol. 269, C118 (1995) | (6) Y. Kuroda, et al.; Biophys. J. 71, 1191 (1996) | (7) M. Kim, et al.; Exp. Cell Res. 231, 235 (1997) | (8) M. Kansha, et al.; Anesthesiology 91, 1798 (1999) | (9) K. Arita, et al.; Biochem. Pharmacol. 60, 905 (2000) | (10) T. Souto-Padron, et al.; Parasitol. Res. 99, 317 (2006) | (11) W. Zhang, et al.; Int. J. Mol. Sci. 12, 2125 (2011) | (12) H.A. Douglas, et al.; J. Neurophysiol. 105, 1482 (2011) | (13) R. Ulferts, et al.; Antimicrob. Agents Chemother. 60, 2627 (2016)