Donepezil hydrochloride
| Code | Size | Price |
|---|
| CDX-D0437-M250 | 250 mg | £164.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
Ambient
Storage:
+20°C
Documents
Further Information
Alternate Names/Synonyms:
(?)-2-[(1-Benzyl-4-piperidyl)methyl]-5,6-dimethoxy-1-indanone hydrochloride; 2,3-Dihydro-5,6-dimethoxy-2-{[1-(phenylmethyl)-4-piperidinyl]methyl}-1H-inden-1-one; E2020
Appearance:
White to off-white crystalline powder.
CAS:
120011-70-3
Class:
6.1
EClass:
32160000
Form (Short):
solid
GHS Symbol:
GHS06
Hazards:
H300
InChi:
InChI=1S/C24H29NO3.ClH/c1-27-22-14-19-13-20(24(26)21(19)15-23(22)28-2)12-17-8-10-25(11-9-17)16-18-6-4-3-5-7-18;/h3-7,14-15,17,20H,8-13,16H2,1-2H3;1H
InChiKey:
XWAIAVWHZJNZQQ-UHFFFAOYSA-N
Long Description:
Chemical. CAS: 120011-70-3. Formula: C24H29NO3 . HCl. MW: 379.5 . 36.5. Synthetic. Potent non-competitive reversible acetylcholinesterase inhibitor that readily crosses the blood-brain barrier to reduce the breakdown of acetylcholine. Displays >1000-fold selectivity for acetylcholinesterase (AChE) over butyrylcholinesterase (BuChE). It is commonly used in the treatment of Alzheimer's disease to improve cognition, memory and behavior.
MDL:
MFCD00881312
Molecular Formula:
C24H29NO3 . HCl
Molecular Weight:
379.5 . 36.5
Package Type:
Vial
PG:
II
Precautions:
P264, P270, P301+P310+P330, P405, P501
Product Description:
Potent non-competitive reversible acetylcholinesterase inhibitor that readily crosses the blood-brain barrier to reduce the breakdown of acetylcholine. Displays >1000-fold selectivity for acetylcholinesterase (AChE) over butyrylcholinesterase (BuChE). It is commonly used in the treatment of Alzheimer's disease to improve cognition, memory and behavior.
Purity:
>98% (T)
Signal Word:
Danger
SMILES:
O=C1C2=CC(OC)=C(OC)C=C2CC1CC3CCN(CC4=CC=CC=C4)CC3.Cl
Solubility Chemicals:
Soluble in water (20 mg/ml). Sparingly soluble in DMSO (1mg/ml), methanol or ethanol.
Source / Host:
Synthetic
Transportation:
Non-hazardous
UN Nummer:
2811
UNSPSC Category:
Biochemical Reagents
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at -20°C.
References
(1) H. Sugimoto, et al.; J. Med. Chem. 38, 4821 (1995) | (2) E.Y. Shintani & K.M. Uchida; Am. J. Health Syst. Pharm. 54, 2805 (1997) (Review) | (3) G. Kryger, et al.; Structure 7, 297 (1999) | (4) H. Sugimoto, et al.; Curr. Med. Chem. 7, 303 (2000) (Review) | (5) D. Munoz-Torrero; Curr. Med. Chem. 15, 2433 (2008) (Review) | (6) H.M. Bryson & P. Benfield; Drugs Aging 10, 234 (1997) (Review)