Ropivacaine hydrochloride monohydrate
| Code | Size | Price |
|---|
| CDX-R0123-M050 | 50 mg | £108.00 |
Quantity:
| CDX-R0123-M250 | 250 mg | £401.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
Ambient
Storage:
+4°C
Documents
Further Information
Alternate Names/Synonyms:
LEA 103; Naropin; (S)-Ropivacaine hydrochloride monohydrate
Appearance:
White to off-white powder.
CAS:
132112-35-7
EClass:
32160000
Form (Short):
liquid
GHS Symbol:
GHS05
Hazards:
H318
InChi:
InChI=1S/C17H26N2O.ClH.H2O/c1-4-11-19-12-6-5-10-15(19)17(20)18-16-13(2)8-7-9-14(16)3;;/h7-9,15H,4-6,10-12H2,1-3H3,(H,18,20);1H;1H2
InChiKey:
VSHFRHVKMYGBJL-UHFFFAOYSA-N
Long Description:
Chemical. CAS: 132112-35-7. Formula: C17H26N2O . HCl . H2O. MW: 274.4 . 36.5 . 18.0. Synthetic. Ropivacaine is a long-acting amide local anaesthetic agent. Ropivacaine is a potent and reversible blocker of sodium channels in nerve fibers. It is a pure S(-)enantiomer and less lipophilic than racemic sodium channel blockers, such as bupivacaine and is less likely to penetrate large myelinated motor fibres, resulting in a relatively reduced motor blockade. Thus, ropivacaine has a greater degree of motor sensory differentiation, which could be useful when motor blockade is undesirable. The reduced lipophilicity is also associated with decreased potential for central nervous system toxicity and cardiotoxicity.
MDL:
MFCD00946578
Molecular Formula:
C17H26N2O . HCl . H2O
Molecular Weight:
274.4 . 36.5 . 18.0
Package Type:
Vial
Precautions:
P280, P305+P351+P338, P310
Product Description:
Ropivacaine is a long-acting amide local anaesthetic agent. Ropivacaine is a potent and reversible blocker of sodium channels in nerve fibers. It is a pure S(-)enantiomer and less lipophilic than racemic sodium channel blockers, such as bupivacaine and is less likely to penetrate large myelinated motor fibres, resulting in a relatively reduced motor blockade. Thus, ropivacaine has a greater degree of motor sensory differentiation, which could be useful when motor blockade is undesirable. The reduced lipophilicity is also associated with decreased potential for central nervous system toxicity and cardiotoxicity.
Purity:
>98% (T)
Signal word:
Danger
SMILES:
CC1=CC=CC(C)=C1NC(C2CCCCN2CCC)=O.O.Cl
Solubility Chemicals:
Soluble in DMSO (25mg/mL), DMF (15mg/ml), ethanol (15mg/ml), methanol or water (2mg/ml).
Source / Host:
Synthetic
Transportation:
Non-hazardous
UNSPSC Category:
Biochemical Reagents
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at +4°C.
References
(1) R.D. Wang, et al.; Exp. Opin. Pharmacother. 2, 2051 (2001) (Review) | (2) T.G. Hansen; Exp. Rev. Neurother. 4, 781 (2004) (Review) | (3) G. Kuthiala & G. Chaudhary; Indian J. Anaesth. 55, 104 (2011) (Review)